Document Detail

No association between DGKH and bipolar disorder in a Scandinavian case-control sample.
MedLine Citation:
PMID:  19478689     Owner:  NLM     Status:  MEDLINE    
Single nucleotide polymorphisms (SNPs) in diacylglycerol kinase eta (DGKH) have recently been shown to be associated with bipolar disorder (BD). To replicate this finding, we carried out a gene-wide genotyping of 36 tagSNPs in DGKH and performed a population-based association study on two Scandinavian samples, with successful genotyping of 594 BD cases and 1421 healthy controls. We found no significant association after multiple-testing correction between any of these SNPs and BD in our sample. Thus, it is unlikely that these genetic variations confer susceptibility to BD in this large Scandinavian sample.
Martin Tesli; Anna K K?hler; Bettina Kulle Andreassen; Thomas Werge; Ole Mors; Erling Mellerup; Pernille Koefoed; Ingrid Melle; Gunnar Morken; Katrine V Wirgenes; Ole A Andreassen; Srdjan Djurovic
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychiatric genetics     Volume:  19     ISSN:  1473-5873     ISO Abbreviation:  Psychiatr. Genet.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-10     Completed Date:  2010-02-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9106748     Medline TA:  Psychiatr Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  269-72     Citation Subset:  IM    
Institute of Psychiatry, Faculty Division Akershus University Hospital, University of Oslo, Oslo, Norway.
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MeSH Terms
Bipolar Disorder / genetics*
Case-Control Studies
Diacylglycerol Kinase / genetics*
European Continental Ancestry Group / genetics*
Genetic Markers
Genetic Predisposition to Disease*
Middle Aged
Reg. No./Substance:
0/Genetic Markers; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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