Document Detail

No association between DGKH and bipolar disorder in a Scandinavian case-control sample.
MedLine Citation:
PMID:  19478689     Owner:  NLM     Status:  MEDLINE    
Single nucleotide polymorphisms (SNPs) in diacylglycerol kinase eta (DGKH) have recently been shown to be associated with bipolar disorder (BD). To replicate this finding, we carried out a gene-wide genotyping of 36 tagSNPs in DGKH and performed a population-based association study on two Scandinavian samples, with successful genotyping of 594 BD cases and 1421 healthy controls. We found no significant association after multiple-testing correction between any of these SNPs and BD in our sample. Thus, it is unlikely that these genetic variations confer susceptibility to BD in this large Scandinavian sample.
Martin Tesli; Anna K K?hler; Bettina Kulle Andreassen; Thomas Werge; Ole Mors; Erling Mellerup; Pernille Koefoed; Ingrid Melle; Gunnar Morken; Katrine V Wirgenes; Ole A Andreassen; Srdjan Djurovic
Related Documents :
18564129 - Identification of association of common aggf1 variants with susceptibility for klippel-...
16429399 - Nonsynonymous snps: validation characteristics, derived allele frequency patterns, and ...
18513279 - Using population mixtures to optimize the utility of genomic databases: linkage disequi...
20155489 - Common genetic variation of insulin-like growth factor-binding protein 1 (igfbp-1), igf...
19228809 - Genetic variation in the multidrug and toxin extrusion 1 transporter protein influences...
19710689 - A functional abcc11 allele is essential in the biochemical formation of human axillary ...
1311299 - A blni restriction map of the salmonella typhimurium lt2 genome.
19148899 - Association of variants in the interleukin-27 and interleukin-12 gene with nasopharynge...
7586149 - A polymorphism at codon 160 of human o6-methylguanine-dna methyltransferase gene in you...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychiatric genetics     Volume:  19     ISSN:  1473-5873     ISO Abbreviation:  Psychiatr. Genet.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-10     Completed Date:  2010-02-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9106748     Medline TA:  Psychiatr Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  269-72     Citation Subset:  IM    
Institute of Psychiatry, Faculty Division Akershus University Hospital, University of Oslo, Oslo, Norway.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bipolar Disorder / genetics*
Case-Control Studies
Diacylglycerol Kinase / genetics*
European Continental Ancestry Group / genetics*
Genetic Markers
Genetic Predisposition to Disease*
Middle Aged
Reg. No./Substance:
0/Genetic Markers; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Cytomegalovirus blood viral load and hearing loss in young children with congenital infection.
Next Document:  Microtubule depolymerization modifies the incorporation of fatty acids into glycerolipids.