Document Detail


No association between DGKH and bipolar disorder in a Scandinavian case-control sample.
MedLine Citation:
PMID:  19478689     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Single nucleotide polymorphisms (SNPs) in diacylglycerol kinase eta (DGKH) have recently been shown to be associated with bipolar disorder (BD). To replicate this finding, we carried out a gene-wide genotyping of 36 tagSNPs in DGKH and performed a population-based association study on two Scandinavian samples, with successful genotyping of 594 BD cases and 1421 healthy controls. We found no significant association after multiple-testing correction between any of these SNPs and BD in our sample. Thus, it is unlikely that these genetic variations confer susceptibility to BD in this large Scandinavian sample.
Authors:
Martin Tesli; Anna K K?hler; Bettina Kulle Andreassen; Thomas Werge; Ole Mors; Erling Mellerup; Pernille Koefoed; Ingrid Melle; Gunnar Morken; Katrine V Wirgenes; Ole A Andreassen; Srdjan Djurovic
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychiatric genetics     Volume:  19     ISSN:  1473-5873     ISO Abbreviation:  Psychiatr. Genet.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-10     Completed Date:  2010-02-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9106748     Medline TA:  Psychiatr Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  269-72     Citation Subset:  IM    
Affiliation:
Institute of Psychiatry, Faculty Division Akershus University Hospital, University of Oslo, Oslo, Norway. m.s.tesli@medisin.uio.no
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MeSH Terms
Descriptor/Qualifier:
Adult
Bipolar Disorder / genetics*
Case-Control Studies
Diacylglycerol Kinase / genetics*
European Continental Ancestry Group / genetics*
Female
Genetic Markers
Genetic Predisposition to Disease*
Humans
Male
Middle Aged
Scandinavia
Chemical
Reg. No./Substance:
0/Genetic Markers; EC 2.7.1.107/Diacylglycerol Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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