| No association of FCRN promoter VNTR polymorphism with the rate of maternal-fetal IgG transfer. | |
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MedLine Citation:
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PMID: 20452034 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The neonatal Fc receptor (FcRn) plays a critical role in maternal-fetal IgG transfer. Recently, a functionally active promoter polymorphism in the FCRN gene, represented by variable number of tandem repeats (VNTR), has been described. We analysed 103 single fetal samples and 103 paired maternal and fetal samples collected from umbilical cord blood of full-term neonates born from the 38th to the 41st week of pregnancy and detected no significant influence of maternal FCRN VNTR genotype on maternal IgG levels or of fetal FCRN VNTR genotype on fetal IgG levels or the fetal/maternal IgG ratio. |
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Authors:
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T Freiberger; B Ravcukov?; L Grodeck?; B Kurecov?; J Jarkovsk?; D Bartonkov?; V Thon; J Litzman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-07 |
Journal Detail:
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Title: Journal of reproductive immunology Volume: 85 ISSN: 1872-7603 ISO Abbreviation: J. Reprod. Immunol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8001906 Medline TA: J Reprod Immunol Country: Ireland |
Other Details:
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Languages: eng Pagination: 193-7 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Molecular Genetics Laboratory, Centre for Cardiovascular Surgery and Transplantation, Pekarska 53, CZ-656 91 Brno, Czech Republic. tomas.freiberger@cktch.cz |
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