Document Detail


No association of the CYP3A5*1 allele with blood pressure and left ventricular mass and geometry: the KORA/MONICA Augsburg echocardiographic substudy.
MedLine Citation:
PMID:  16822233     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A polymorphism in the cytochrome P450 3A CYP3A5 enzyme has been implicated in BP (blood pressure) control and arterial hypertension. Carriers of the CYP3A5*1 allele had high, whereas homozygous carriers of the CYP3A5*3 allele exhibit low, CYP3A5 expression in the kidney, where CYP3A5 represents the major CYP3A enzyme. The aim of the present study was to investigate the association of the CYP3A5*1 allele with BP, arterial hypertension, LVM [(left ventricular) mass] and LV geometry in a large Caucasian-population-based cohort. We compared BP, LVM and the prevalence of hypertension between carriers (CYP3A5*1/*1 and CYP3A5*1/*3 genotypes) and non-carriers (CYP3A5*3/*3 genotype) of the CYP3A5*1 allele in the echocardiographic substudy of the third MONICA (MONItoring trends and determinants in CArdiovascular disease) Augsburg survey. After exclusion of 269 individuals who were taking antihypertensive medication, 530 women and 554 men were available for analysis, revealing allele frequencies of 5.8 and 94.2% for the CYP3A5*1 and CYP3A5*3 alleles respectively. Overall, the presence of the CYP3A5*1 allele exhibited no effect on systolic or diastolic BP in either gender. One-third of the individuals in this cohort were hypertensive (BP > or =140/90 mmHg), and the genotype distribution between normotensive and hypertensive individuals revealed no association between CYP3A5*1 and hypertension after adjustment for age, BMI and gender (odds ratio, 1.02; P=0.92). Moreover, no effect of CYP3A5*1 on LVM, thickness of the septal and posterior wall and LV end-diastolic diameter was found. We conclude that CYP3A5*1 exhibits no significant effect on BP, LVM and LV geometry in the KORA/MONICA echocardiographic substudy.
Authors:
Wolfgang Lieb; Juliane Bolbrinker; Angela Döring; Hans-Werner Hense; Jeanette Erdmann; Heribert Schunkert; Reinhold Kreutz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  111     ISSN:  1470-8736     ISO Abbreviation:  Clin. Sci.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-09     Completed Date:  2007-09-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  365-72     Citation Subset:  IM    
Affiliation:
Medizinische Klinik 2, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Pressure / physiology
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System / genetics*
Echocardiography
Female
Genotype
Glomerular Filtration Rate / physiology
Humans
Hypertension / genetics*,  physiopathology
Hypertrophy, Left Ventricular / genetics*,  physiopathology
Male
Middle Aged
Polymorphism, Genetic / genetics*
Chemical
Reg. No./Substance:
9035-51-2/Cytochrome P-450 Enzyme System; EC 1.14.14.1/CYP3A5 protein, human; EC 1.14.14.1/Cytochrome P-450 CYP3A

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