Document Detail


No association of ALOX5AP polymorphisms with risk of MRI-defined brain infarcts.
MedLine Citation:
PMID:  22074807     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene has been associated with stroke. The majority of the reported ALOX5AP associations have considered non-radiologically confirmed infarcts as the stroke phenotype. We assessed the association of genetic variants in ALOX5AP with stroke defined by the presence of infarcts on brain magnetic resonance imaging (MRI). We studied 202 persons with MRI-defined brain infarcts and 487 healthy individuals of Caribbean Hispanic ancestry. Another sample of European ancestry comprised 1823 persons with MRI-defined brain infarct and 7578 control subjects. Subjects were genotyped for the 4 single nucleotide polymorphisms (SNPs) that define ALOX5AP HapA haplotype. No association was found between SNPs and MRI-defined brain infarcts. Our data do not support the hypothesis that variants in ALOX5AP are associated with risk of MRI-defined brain infarcts.
Authors:
Sandra Barral; Israel Fernández-Cadenas; Joshua C Bis; Joan Montaner; Arfan M Ikram; Lenore J Launer; Myriam Fornage; Helena Schmidt; Adam M Brickman; Sudha Seshadri; Richard Mayeux
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural     Date:  2011-11-09
Journal Detail:
Title:  Neurobiology of aging     Volume:  33     ISSN:  1558-1497     ISO Abbreviation:  Neurobiol. Aging     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-01-16     Completed Date:  2012-09-28     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  8100437     Medline TA:  Neurobiol Aging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  629.e1-3     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
5-Lipoxygenase-Activating Proteins / genetics*
Brain Infarction / ethnology,  genetics*,  pathology
Caribbean Region / ethnology
Case-Control Studies
Cohort Studies
Genetic Association Studies*
Haplotypes / genetics
Hispanic Americans / ethnology,  genetics
Humans
Magnetic Resonance Imaging
Polymorphism, Single Nucleotide / genetics*
Prospective Studies
Grant Support
ID/Acronym/Agency:
N01 HC055019/HC/NHLBI NIH HHS; P01 AG0027232/AG/NIA NIH HHS; R01 AG033193-01/AG/NIA NIH HHS; R01 AG033193-02/AG/NIA NIH HHS; R01 AG033193-03/AG/NIA NIH HHS; R01 AG037212/AG/NIA NIH HHS; R01 AG037212-01/AG/NIA NIH HHS; R01 AG037212-02/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/5-Lipoxygenase-Activating Proteins; 0/ALOX5AP protein, human
Comments/Corrections

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