Document Detail

No apparent difference in the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on the sympathetic system in NMRI and C57 BL/6 mice.
MedLine Citation:
PMID:  2123046     Owner:  NLM     Status:  MEDLINE    
The parkinsonism-inducing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has been shown to possess marked species as well as strain differences in toxicity on central catecholaminergic systems. In the present study the effects on the peripheral sympathetic nervous system following treatment with MPTP, as well as its metabolite 1-methyl-4-phenylpyridine (MPP+) and the catecholamine neurotoxin 6-hydroxydopamine (6-OHDA) were studied in mice of the NMRI and C57 BL/6 strains, two strains that possess marked difference in MPTP toxicity on central catecholaminergic neurons. No strain differences in the depletions of noradrenaline (NA) in iris and heart auricula and of NA and dopamine (DA) in superior cervical ganglion or in the reduction of the in vitro [3H]NA uptake in iris or heart auricula were found following MPTP treatment (2 X 40 mg/kg s.c., 2 and 7 days). Treatment with the NA uptake blocker desipramine (DMI) did not affect the MPTP-induced NA depletion in either strain. Following treatment with MPP+ (30 mg/kg i.v., 7 days) no differences in the two strains were seen on the reduction of NA levels in iris and heart auricula or decrease in [3H]NA uptake. In addition, no differences were found on NA levels in iris and heart auricula after 6-OHDA treatment (15 mg/kg i.v., 7 days). The data indicate that in the NMRI and C57 BL/6 mice peripheral NA neurons do not possess any notable strain difference in the vulnerability to MPTP or in the mechanism of action of MPTP.
J Luthman; E Sundström
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicology letters     Volume:  54     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1990-12-31     Completed Date:  1990-12-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  83-92     Citation Subset:  IM    
Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden.
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MeSH Terms
1-Methyl-4-phenylpyridinium / toxicity
Heart / drug effects
Hydroxydopamines / toxicity
Injections, Subcutaneous
Iris / drug effects,  metabolism
MPTP Poisoning*
Mice, Inbred C57BL
Norepinephrine / metabolism
Species Specificity
Sympathetic Nervous System / drug effects*
Reg. No./Substance:
0/Hydroxydopamines; 1199-18-4/Oxidopamine; 48134-75-4/1-Methyl-4-phenylpyridinium; 51-41-2/Norepinephrine

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