Document Detail

No adverse effects of statins on muscle function and health-related parameters in the elderly: An exercise study.
MedLine Citation:
PMID:  22288788     Owner:  NLM     Status:  Publisher    
The aim of the present study was to investigate the effects of a repeated bout of eccentric exercise on health-related parameters and muscle performance on subjects undergoing atorvastatin therapy. Twenty-eight elderly men participated in the investigation and were assigned either in a control (n = 14) or in a statin therapy group (n = 14). All participants performed two isokinetic eccentric exercise bouts separated by 3 weeks. Muscle damage indices, resting energy expenditure, substrate metabolism, lipid and lipoprotein profile, as well as insulin sensitivity, were evaluated before and after eccentric. No differences in muscle function were observed between the two groups either at rest or after exercise. Eccentric exercise increased resting energy expenditure, increased fat oxidation, improved lipid profile, and increased insulin resistance 2 days after both eccentric exercise bouts. However, these changes appeared to lesser extent after the second bout. No differences were observed in the responses in the health-related parameters in the control and in the statin therapy group. Eccentric exercise affected similarly the control and the atorvastatin-treated individuals. The present results indicate that atorvastatin-treated elderly individuals may participate in various physical activities, even high-intensity muscle-damaging activities, without negative impact on muscle function and adaptation.
G Panayiotou; V Paschalis; M G Nikolaidis; A A Theodorou; C K Deli; N Fotopoulou; I G Fatouros; Y Koutedakis; M Sampanis; A Z Jamurtas
Related Documents :
2318028 - Neuropeptide y is released together with noradrenaline from the human heart during exer...
17317748 - Effects of hypoxia on diaphragmatic fatigue in highly trained athletes.
16896738 - Effects of low and high levels of moderate hypoxia on anaerobic energy release during s...
7779418 - Relationship between tumour oxygenation, bioenergetic status and radiobiological hypoxi...
8808538 - Atrial natriuretic factor responses to submaximal and maximal exercise.
9445308 - Hyperventilation induces release of cytokines from perfused mouse lung.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-31
Journal Detail:
Title:  Scandinavian journal of medicine & science in sports     Volume:  -     ISSN:  1600-0838     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111504     Medline TA:  Scand J Med Sci Sports     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 John Wiley & Sons A/S.
Institute of Human Performance and Rehabilitation, Center for Research and Technology - Thessaly, Trikala, Greece; Laboratory of Exercise, Health and Human Performance, Research Center, European University of Cyprus, Nicosia, Cyprus.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparative study between depression in Korean elderly with mild cognitive impairment and normal cog...
Next Document:  Nonpharmacological Approaches to the Management of Chronic Pain in Community-Dwelling Older Adults: ...