Document Detail


No adaptation to UV-induced immunosuppression and DNA damage following exposure of mice to chronic UV-exposure.
MedLine Citation:
PMID:  16504533     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is well known that ultraviolet (UV) radiation induces erythema, immunosuppression and carcinogenesis. We hypothesized that chronic exposure to solar UV radiation induces adaptation that eventually prevents the suppression of acquired immunity. We studied adaptation for UV-induced immunosuppression after chronic exposure of mice to a suberythemal dose of solar simulated radiation (SSR) with Cleo Natural lamps, and subsequent exposure to an immunosuppressive dose of solar or UVB radiation (TL12). After UV dosing, the mice were sensitized and challenged with either diphenylcyclopropenone (DPCP) or picryl chloride (PCl). To assess the adaptation induced by solar simulated radiation, we measured the proliferative response and cytokine production of skin-draining lymph node cells after immunization to DPCP, the contact hypersensitivity (CHS) response to PCl, and thymine-thymine (T-T) cyclobutane dimers in the skin of mice. After induction of immunosuppression by SSR or by TL12 lamps, the proliferative response of draining lymph node cells after challenge with DPCP, or the CHS after challenge with PCl, showed significant suppression of the immune response. Chronic irradiation from SSR preceding the immunosuppressive dose of UV failed to restore the suppressed immune response. Reduced lipopolysaccharide-triggered cytokine production (of IL-12p40, IFN-gamma, IL-6 and TNF-alpha) by draining lymph node cells of mice sensitized and challenged with DPCP indicated that no adaptation is induced. In addition, the mice were not protected from T-T dimer DNA damage after chronic solar irradiation. Our studies reveal no evidence that chronic exposure to low doses of SSR induces adaptation to UV-induced suppression of acquired immunity.
Authors:
Peter A Steerenberg; Frieda Daamen; Eefke Weesendorp; Henk Van Loveren
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Publication Detail:
Type:  Journal Article     Date:  2006-02-28
Journal Detail:
Title:  Journal of photochemistry and photobiology. B, Biology     Volume:  84     ISSN:  1011-1344     ISO Abbreviation:  J. Photochem. Photobiol. B, Biol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-13     Completed Date:  2006-10-04     Revised Date:  2007-07-23    
Medline Journal Info:
Nlm Unique ID:  8804966     Medline TA:  J Photochem Photobiol B     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  28-37     Citation Subset:  IM    
Affiliation:
Laboratory for Toxicology, Pathology and Genetics, National Institute for Public Health and the Environment, P.O. Box 1, 3720 BA Bilthoven, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological / radiation effects*
Animals
Cell Proliferation / radiation effects
Cyclopropanes / immunology
Cytokines / metabolism
DNA Damage*
Dermatitis, Contact / immunology
Dose-Response Relationship, Radiation
Immunosuppression*
Lymphocyte Activation / radiation effects
Mice
Mice, Inbred BALB C
Radiation Tolerance / immunology*
Skin / drug effects,  immunology,  radiation effects
Sunlight
Time Factors
Ultraviolet Rays*
Chemical
Reg. No./Substance:
0/Cyclopropanes; 0/Cytokines; 886-38-4/diphenylcyclopropenone

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