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No Survival Benefit From Postoperative Adjuvant Chemotherapy After D2 Radical Resection for the Patients With Stage II Gastric Cancer.
MedLine Citation:
PMID:  20838324     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVE: : To evaluate the effect of 2 regimens of postoperative combination chemotherapies on the prognosis of early stage gastric cancer patients.
METHODS: : A total of 268 patients with stage II gastric cancer underwent D2 resection in our Cancer Center between January 1990 and December 2006 were recruited. Among them, 34 patients received the FAM regimen (5-fluorouracil [5-FU] 600 mg/m intravenous [IV] drip on days 1, 8, 29, and 36; doxorubicin 30 mg/m IV bolus injection on days 1 and 29; and mitomycin-C 10 mg/m IV bolus injection on day 1; repeated every 8 weeks) and 81 patients received the FOLFOX regimen (oxaliplatin 100 mg/m IV drip on days 1 and 15; leucovorin 400 mg/m IV drip on days 1 and 15; 5-FU 400 mg/m IV bolus injection; 5-FU 2.4/3.0 mg/m continuous IV infusion for 48 hours on day 1, 2, 15, and 16; repeated every 4 weeks for at least 4 cycles). Patients were followed-up until December 2008. The Kaplan-Meier method was used to compare survival rates between treatment groups.
RESULTS: : The 1-, 3-, 5-, and 10-year survival rates for the patients who received postoperative chemotherapy versus the patients who underwent surgery only were 98%, 84%, 58%, 18% versus 96%, 78%, 59%, 22%, respectively (P > 0.05). Furthermore, the survival rates for patients who received the FAM and FOLFOX regimens were not significantly different (P > 0.05).
CONCLUSIONS: : Postoperative adjuvant chemotherapy did not produce survival benefits for the patients with stage II gastric cancer. Randomized controlled clinical trials are demanded to confirm the finding from this study.
Shi Chen; Ying-Bo Chen; Zhi-Wei Zhou; Wei Li; Xiao-Wei Sun; Da-Zhi Xu; Yuan-Fang Li; Yuan-Xiang Guan; Xing-Yu Feng; You-Qing Zhan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical oncology     Volume:  34     ISSN:  1537-453X     ISO Abbreviation:  Am. J. Clin. Oncol.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207754     Medline TA:  Am J Clin Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  309-13     Citation Subset:  IM    
From the *State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People's Republic of China; and †Department of Abdominal Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, People's Republic of China.
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