Document Detail


No major differences in 30-day outcomes in high-risk patients randomized to off-pump versus on-pump coronary bypass surgery: the best bypass surgery trial.
MedLine Citation:
PMID:  20083683     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Off-pump coronary artery bypass grafting compared with coronary revascularization with cardiopulmonary bypass seems safe and results in about the same outcome in low-risk patients. Observational studies indicate that off-pump surgery may provide more benefit in high-risk patients. Our objective was to compare 30-day outcomes in high-risk patients randomized to coronary artery bypass grafting without or with cardiopulmonary bypass. METHODS AND RESULTS: We randomly assigned 341 patients with a EuroSCORE > or = 5 and 3-vessel coronary disease to undergo coronary artery bypass grafting without or with cardiopulmonary bypass. Patients were followed through the Danish National Patient Registry. The primary outcome was a composite of adverse cardiac and cerebrovascular events (ie, all-cause mortality, acute myocardial infarction, cardiac arrest with successful resuscitation, low cardiac output syndrome/cardiogenic shock, stroke, and coronary reintervention). An independent adjudication committee blinded to treatment allocation assessed the outcomes. Baseline characteristics were well balanced between groups. The mean number of grafts per patient did not differ significantly between groups (3.22 in off-pump group and 3.34 in on-pump group; P=0.11). Fewer grafts were performed to the lateral part of the left ventricle territory during off-pump surgery (0.97 versus 1.14 after on-pump surgery; P=0.01). No significant differences in the composite primary outcome (15% versus 17%; P=0.48) or the individual components were found at 30-day follow-up. CONCLUSIONS: Both off- and on-pump coronary artery bypass grafting can be performed in high-risk patients with low short-term complications. CLINICAL TRIAL REGISTRATION- clinicaltrials.gov. Identifier: NCT00120991.
Authors:
Christian H Møller; Mario J Perko; Jens T Lund; Lars W Andersen; Henning Kelbaek; Jan K Madsen; Per Winkel; Christian Gluud; Daniel A Steinbrüchel
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-01-18
Journal Detail:
Title:  Circulation     Volume:  121     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-03     Completed Date:  2010-03-11     Revised Date:  2010-11-01    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  498-504     Citation Subset:  AIM; IM    
Affiliation:
Cardiothoracic Surgery, Department 2152, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark. chm@ctu.rh.dk
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00120991
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Cardiac Output, Low / epidemiology
Coronary Artery Bypass / adverse effects,  methods*
Coronary Artery Bypass, Off-Pump / adverse effects,  methods*
Coronary Artery Disease / surgery*
Female
Follow-Up Studies
Heart Arrest / epidemiology
Humans
Male
Myocardial Infarction / epidemiology
Risk Factors
Stroke / epidemiology
Treatment Outcome
Comments/Corrections
Comment In:
Circulation. 2010 Oct 26;122(17):e497; author reply e499   [PMID:  20975006 ]
Circulation. 2010 Oct 26;122(17):e498; author reply e499   [PMID:  20975007 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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