| No laughing matter: intranasal oxytocin administration changes functional brain connectivity during exposure to infant laughter. | |
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MedLine Citation:
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PMID: 22189289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Infant laughter is a rewarding experience. It activates neural reward circuits and promotes parental proximity and care, thus facilitating parent-infant attachment. The neuropeptide oxytocin might enhance the incentive salience of infant laughter by modulating neural circuits related to the perception of infant cues. In a randomized controlled trial with functional magnetic resonance imaging we investigated the influence of intranasally administered oxytocin on functional brain connectivity in response to infant laughter. Blood oxygenation level-dependent responses to infant laughter were measured in 22 nulliparous women who were administered oxytocin and 20 nulliparous women who were administered a placebo. Elevated oxytocin levels reduced activation in the amygdala during infant laughter and enhanced functional connectivity between the amygdala and the orbitofrontal cortex, the anterior cingulate, the hippocampus, the precuneus, the supramarginal gyri, and the middle temporal gyrus. Increased functional connectivity between the amygdala and regions involved in emotion regulation may reduce negative emotional arousal while enhancing the incentive salience of the infant laughter. |
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Authors:
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Madelon M E Riem; Marinus H van IJzendoorn; Mattie Tops; Maarten A S Boksem; Serge A R B Rombouts; Marian J Bakermans-Kranenburg |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2011-12-21 |
Journal Detail:
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Title: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Volume: 37 ISSN: 1740-634X ISO Abbreviation: Neuropsychopharmacology Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-03-15 Completed Date: 2012-07-20 Revised Date: 2013-04-01 |
Medline Journal Info:
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Nlm Unique ID: 8904907 Medline TA: Neuropsychopharmacology Country: England |
Other Details:
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Languages: eng Pagination: 1257-66 Citation Subset: IM |
Affiliation:
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Centre for Child and Family Studies, Leiden University, Leiden, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Administration, Intranasal Adult Brain / blood supply, drug effects* Brain Mapping* Double-Blind Method Female Humans Image Processing, Computer-Assisted Infant Laughter* Magnetic Resonance Imaging Middle Aged Oxygen / blood Oxytocics / administration & dosage* Oxytocin / administration & dosage* Reward Twin Studies as Topic Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Oxytocics; 50-56-6/Oxytocin; 7782-44-7/Oxygen |
| Comments/Corrections | |
Erratum In:
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Neuropsychopharmacology. 2012 Aug;37(9):2174 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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