Document Detail


No clinically significant drug-resistance mutations in HIV-1 subtype C-infected women after discontinuation of NRTI-based or PI-based HAART for PMTCT in Botswana.
MedLine Citation:
PMID:  23542639     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Risk of developing drug resistance after stopping antiretroviral regimens to prevent mother-to-child HIV-1 transmission is unknown. The Mma Bana Study randomized treatment-naive pregnant women with CD4 ≥200 cells per cubic millimeter to receive either abacavir/zidovudine/lamivudine [triple nucleoside reverse transcriptase inhibitor (NRTI) arm] or lopinavir/ritonavir/zidovudine/lamivudine [protease inhibitor (PI) arm]. Drugs were discontinued after 6 months of breastfeeding. One month after discontinuation, 29 NRTI arm samples and 25 PI arm samples were successfully genotyped. No clinically significant antiretroviral resistance mutations were detected. Eight minor resistance mutations were found among 11 (20%) women (3 from NRTI arm and 8 from PI arm), occurring at similar frequencies to those reported in HIV-1 subtype C treatment-naive cohorts.
Authors:
Sajini Souda; Simani Gaseitsiwe; Nathan Georgette; Kathleen Powis; Daisy Moremedi; Thato Iketleng; Jean Leidner; Claire Moffat; Anthony Ogwu; Shahin Lockman; Sikhulile Moyo; Mompati Mmalane; Rosemary Musonda; Joseph Makhema; Max Essex; Roger Shapiro
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes (1999)     Volume:  63     ISSN:  1944-7884     ISO Abbreviation:  J. Acquir. Immune Defic. Syndr.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-10-21     Completed Date:  2013-11-12     Revised Date:  2014-08-18    
Medline Journal Info:
Nlm Unique ID:  100892005     Medline TA:  J Acquir Immune Defic Syndr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  572-7     Citation Subset:  IM; X    
Data Bank Information
Bank Name/Acc. No.:
GENBANK/KC204763;  KC204764;  KC204765;  KC204766;  KC204767;  KC204768;  KC204769;  KC204770;  KC204771;  KC204772;  KC204773;  KC204774;  KC204775;  KC204776;  KC204777;  KC204778;  KC204779;  KC204780;  KC204781;  KC204782;  KC204783;  KC204784;  KC204785;  KC204786;  KC204787;  KC204788;  KC204789;  KC204790;  KC204791;  KC204792;  KC204793;  KC204794;  KC204795;  KC204796;  KC204797;  KC204798;  KC204799;  KC204800;  KC204801;  KC204802;  KC204803;  KC204804;  KC204805;  KC204806;  KC204807;  KC204808;  KC204809;  KC204810;  KC852928;  KC852929;  KC852930;  KC852931;  KC852932;  KC852933
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-HIV Agents / administration & dosage*
Antiretroviral Therapy, Highly Active / methods*
Botswana
Drug Resistance, Viral*
Female
Genotype
HIV Infections / drug therapy*,  transmission,  virology*
HIV-1 / drug effects,  genetics*,  isolation & purification
Humans
Infectious Disease Transmission, Vertical / prevention & control
Molecular Sequence Data
Mutation, Missense*
Pregnancy
Sequence Analysis, DNA
Withholding Treatment
Grant Support
ID/Acronym/Agency:
K23 HD070774/HD/NICHD NIH HHS; U01 AI066454/AI/NIAID NIH HHS; U01AI066454/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Anti-HIV Agents
Comments/Corrections

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