Document Detail

No Cerebral or Cervical Venous Insufficiency in US Veterans With Multiple Sclerosis.
MedLine Citation:
PMID:  21825217     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To determine if chronic cerebral venous insufficiency exists in patients with multiple sclerosis (MS) using ultrasonography and 4-dimensional color Doppler ultrasonography examination and unverified criteria proposed by Zamboni et al. DESIGN: Patients with MS and clinically isolated syndrome were matched by age and sex with subjects with migraine or no neurological disease. All subjects underwent gray-scale, color, and spectral Doppler ultrasonography examination of the internal jugular veins (IJVs), vertebral veins, and deep cerebral veins for stenosis, absence of signal, and reflux. SETTING: Academic MS center. Patients  All patients with MS fulfilled revised McDonald criteria for the diagnosis of MS. Patients with clinically isolated syndrome exhibited a typical transient focal neurological deficit and had magnetic resonance imaging lesions typical of MS. Control subjects were recruited from the VA migraine clinic or staff. MAIN OUTCOME MEASURES: Five parameters of venous outflow used by Zamboni et al were examined: (1) IJV or vertebral vein reflux, (2) deep cerebral vein reflux, (3) IJV stenosis, (4) absence of flow in IJVs or vertebral veins, and (5) change in cross-sectional area of the IJV with postural change. RESULTS: There was no significant difference in the number and type of venous outflow abnormalities in patients with MS compared with controls. CONCLUSION: This study does not support the theory that chronic cerebral venous insufficiency exists in MS.
Ellen Marder; Pramod Gupta; Benjamin M Greenberg; Elliot M Frohman; Amer M Awad; Bridget Bagert; Olaf Stüve
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-8
Journal Detail:
Title:  Archives of neurology     Volume:  -     ISSN:  1538-3687     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Medical Service (Drs Marder and Stüve), and Radiology Division (Dr Gupta), VA North Texas Health Care System, and Department of Neurology, University of Texas Southwestern Medical Center at Dallas (Drs Marder, Greenberg, Frohman, and Stüve), Dallas; and Baton Rouge Neurology Associates, Baton Rouge General Medical Center, Baton Rouge (Dr Awad), and Department of Neurology, Ochsner Clinic Foundation, New Orleans (Dr Bagert), Louisiana.
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