Document Detail

No Association between ACE Gene Variation and Endurance Athlete Status in Ethiopians.
MedLine Citation:
PMID:  20798657     Owner:  NLM     Status:  In-Data-Review    
PURPOSE: : The most widely studied candidate gene for endurance performance is the angiotensin-converting enzyme (ACE) gene. The best endurance runners in the world hail from Kenya and Ethiopia, so the lack of association between the ACE gene and elite endurance athlete status we previously reported in Kenyans requires replication in Ethiopians.
METHODS: : DNA was extracted from buccal swabs collected from subjects filling four groups: elite endurance runners from the Ethiopian national athletics team specializing in 5 km to marathon distances (n = 76), controls demographically matched to the elite endurance athletes (n = 410), controls representing the general Ethiopian population (n = 317), and sprint and power event athletes from the Ethiopian national athletics team (n = 38). ACE I/D and A22982G (rs4363) genotype frequencies were determined for each of these groups, and differences between groups were assessed using χ tests.
RESULTS: : There were no significant deviations from Hardy-Weinberg equilibrium in endurance athletes or either control group. Endurance athletes did not differ significantly in ACE I/D genotype frequency when compared with the endurance athlete-matched control group (P = 0.16), general controls (P = 0.076), or sprint and power athletes (P = 0.39) (endurance athletes: 15.8% II, endurance athlete-matched controls: 8.8% II, general controls: 7.6% II, sprint and power athletes: 10.5% II). Similarly, no significant differences were found in ACE A22982G genotype between groups (endurance athletes: 13.2% AA, endurance athlete-matched controls: 12.2% AA, general controls: 12.0% AA, sprint and power athletes: 13.2%; endurance athletes vs endurance athlete-matched controls: P = 0.97, endurance athletes vs general controls: P = 0.95, endurance athletes vs sprint and power athletes: P = 0.52).
CONCLUSIONS: : As previously shown in elite Kenyan athletes, ACE I/D and A22982G polymorphisms are not associated with elite endurance athlete status in Ethiopians.
Garrett I Ash; Robert A Scott; Michael Deason; Tom A Dawson; Bezabih Wolde; Zeru Bekele; Solomon Teka; Yannis P Pitsiladis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  43     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  590-7     Citation Subset:  IM; S    
1Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, UNITED KINGDOM; 2College of Medicine, Veterinary and Life Sciences, Institute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow, UNITED KINGDOM; 3International Centre for East African Running Science (ICEARS), Moi University, Eldoret, KENYA; 4QinetiQ Group, UK; and 5Department of Sport Science, Addis Ababa University, Addis Ababa, ETHIOPIA.
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