Document Detail

Nizatidine and ranitidine in the short-term treatment of duodenal ulcer: a cooperative double-blind study of once-daily bedtime administration.
MedLine Citation:
PMID:  2897784     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to assess the clinical efficacy and safety of a new H2-antagonist, nizatidine (N), administered as a single bedtime dose of 300 mg, compared with ranitidine (R) at the same dosage, in the short-term treatment of duodenal ulcer. One hundred forty one patients were included in the study: 70 were treated with N and 71 with R. During the study, three patients were withdrawn for unwanted effects not related to the treatment, and therefore, 69 patients per group were studied. After 4 wk of treatment, 58 patients treated with N (84.1%) and 55 in the group treated with R (77.5%), showed complete endoscopic ulcer healing (p greater than 0.5). The corresponding figure after 8 wk of therapy was 64 (94.2%) and 65 (94.2%) (p greater than 0.5). A similar effect on pain relief was observed: 42% of patients in both groups became asymptomatic after 4 wk. After 8 wk, the percentage rose to 84.2% in the group treated with N and 87.0% in the R group (p greater than 0.5). In both groups, only minor side effects occurred, not requiring drug discontinuation. These data show that nizatidine in a single bedtime dose of 300 mg is as effective and safe as ranitidine at the same dosage, and represents therefore a valid alternative to the usual H2-antagonists.
F Pace; E Colombo; A Ferrara; A Prada; F Rocca; G Bianchi Porro
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  83     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-06-29     Completed Date:  1988-06-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  643-5     Citation Subset:  IM    
Gastrointestinal Unit, Ospedale L. Sacco, Milano, Italy.
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MeSH Terms
Clinical Trials as Topic
Double-Blind Method
Drug Administration Schedule
Duodenal Ulcer / drug therapy*
Histamine H2 Antagonists / administration & dosage,  adverse effects,  therapeutic use*
Middle Aged
Ranitidine / therapeutic use*
Thiazoles / administration & dosage,  adverse effects,  therapeutic use*
Reg. No./Substance:
0/Histamine H2 Antagonists; 0/Thiazoles; 66357-35-5/Ranitidine; 76963-41-2/Nizatidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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