| Nizatidine and ranitidine in the short-term treatment of duodenal ulcer: a cooperative double-blind study of once-daily bedtime administration. | |
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MedLine Citation:
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PMID: 2897784 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present study was to assess the clinical efficacy and safety of a new H2-antagonist, nizatidine (N), administered as a single bedtime dose of 300 mg, compared with ranitidine (R) at the same dosage, in the short-term treatment of duodenal ulcer. One hundred forty one patients were included in the study: 70 were treated with N and 71 with R. During the study, three patients were withdrawn for unwanted effects not related to the treatment, and therefore, 69 patients per group were studied. After 4 wk of treatment, 58 patients treated with N (84.1%) and 55 in the group treated with R (77.5%), showed complete endoscopic ulcer healing (p greater than 0.5). The corresponding figure after 8 wk of therapy was 64 (94.2%) and 65 (94.2%) (p greater than 0.5). A similar effect on pain relief was observed: 42% of patients in both groups became asymptomatic after 4 wk. After 8 wk, the percentage rose to 84.2% in the group treated with N and 87.0% in the R group (p greater than 0.5). In both groups, only minor side effects occurred, not requiring drug discontinuation. These data show that nizatidine in a single bedtime dose of 300 mg is as effective and safe as ranitidine at the same dosage, and represents therefore a valid alternative to the usual H2-antagonists. |
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Authors:
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F Pace; E Colombo; A Ferrara; A Prada; F Rocca; G Bianchi Porro |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: The American journal of gastroenterology Volume: 83 ISSN: 0002-9270 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 1988 Jun |
Date Detail:
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Created Date: 1988-06-29 Completed Date: 1988-06-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 643-5 Citation Subset: IM |
Affiliation:
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Gastrointestinal Unit, Ospedale L. Sacco, Milano, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Clinical Trials as Topic Double-Blind Method Drug Administration Schedule Duodenal Ulcer / drug therapy* Female Histamine H2 Antagonists / administration & dosage, adverse effects, therapeutic use* Humans Male Middle Aged Nizatidine Ranitidine / therapeutic use* Thiazoles / administration & dosage, adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Histamine H2 Antagonists; 0/Thiazoles; 66357-35-5/Ranitidine; 76963-41-2/Nizatidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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