Document Detail


Nitroxyl (HNO): the Cinderella of the nitric oxide story.
MedLine Citation:
PMID:  18835046     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Until recently, most of the biological effects of nitric oxide (NO) have been attributed to its uncharged state (NO*), yet NO can also exist in the reduced state as nitroxyl (HNO or NO(-)). Putatively generated from both NO synthase (NOS)-dependent and -independent sources, HNO is rapidly emerging as a novel entity with distinct pharmacology and therapeutic advantages over its redox sibling, NO*. Thus, unlike NO*, HNO can target cardiac sarcoplasmic ryanodine receptors to increase myocardial contractility, can interact directly with thiols and is resistant to both scavenging by superoxide (*O2-) and tolerance development. HNO donors are protective in the setting of heart failure in which NO donors have minimal impact. Here, we discuss the unique pharmacology of HNO versus NO* and highlight the therapeutic potential of HNO donors in the treatment of cardiovascular disease.
Authors:
Jennifer C Irvine; Rebecca H Ritchie; Joanne L Favaloro; Karen L Andrews; Robert E Widdop; Barbara K Kemp-Harper
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-10-01
Journal Detail:
Title:  Trends in pharmacological sciences     Volume:  29     ISSN:  0165-6147     ISO Abbreviation:  Trends Pharmacol. Sci.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-25     Completed Date:  2009-06-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906158     Medline TA:  Trends Pharmacol Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  601-8     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Monash University, Clayton, VIC, Australia.
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MeSH Terms
Descriptor/Qualifier:
Alcoholism / drug therapy
Animals
Antioxidants / chemistry,  pharmacology*
Cardiovascular Diseases / drug therapy
Humans
Nitric Oxide / metabolism*
Nitric Oxide Donors / pharmacology,  therapeutic use
Nitrogen Oxides / chemistry,  metabolism*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Nitric Oxide Donors; 0/Nitrogen Oxides; 10102-43-9/Nitric Oxide; 14332-28-6/nitroxyl

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