| Nitrovasodilator effects on intraocular pressure and outflow facility in monkeys. | |
| | |
MedLine Citation:
|
PMID: 8157106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The nitrovasodilators nitroglycerin (NTG) and hydralazine (HZN) were investigated for their effects on intraocular pressure (IOP) and outflow facility in the cynomolgus monkey eye in vivo. Fifty microliters of 0.1% HZN were administered topically in masked, randomized, crossover, placebo controlled trials, and by intracameral perfusion. Both NTG and HZN decreased IOP (mean IOP decrease with NTG 4.40 +/- 2.11 (S.E.M.) (+/- 4.7, S.D.) mmHg, P < 0.01, n = 5, with HZN 3.15 +/- 0.85 (S.E.M.) (+/- 2.3, S.D.) mmHg, P = 0.01, n = 7). Outflow facility increased by 92% (P < 0.05) after intracameral bolus injection of 10(-3) mol l-1 NTG, but not at lower doses. Intracameral HZN caused a significant increase in facility of outflow of 28% (P < 0.05) when perfused at a constant concentration of 10(-5) mol l-1, but not at certain other concentrations. These results demonstrate the capacity for topically applied NTG and HZN to reduce IOP in the living primate eye. They further suggest that, at certain drug doses, but not others, the IOP reduction may be mediated, in part, by an action on the outflow apparatus. |
| | |
Authors:
|
J S Schuman; K Erickson; J A Nathanson |
Related Documents
:
|
20362856 - Effect of laser in situ keratomileusis on rebound tonometry and goldmann applanation to... 67096 - Orthograde and retrograde axoplasmic transport during acute ocular hypertension in the ... 18004586 - Circadian changes of intraocular pressure and ocular perfusion pressure after timolol o... 11434936 - The pharmacology of bimatoprost (lumigan). 10339366 - Permeate flux in crossflow ultrafiltration under intermediate pressures. 16924166 - Nebivolol: new therapy update. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Experimental eye research Volume: 58 ISSN: 0014-4835 ISO Abbreviation: Exp. Eye Res. Publication Date: 1994 Jan |
Date Detail:
|
Created Date: 1994-05-19 Completed Date: 1994-05-19 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0370707 Medline TA: Exp Eye Res Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 99-105 Citation Subset: IM |
Affiliation:
|
New England Eye Center, Tufts University School of Medicine, Boston, MA 02111. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Aqueous Humor / drug effects* Depression, Chemical Dose-Response Relationship, Drug Female Hydralazine / pharmacology* Intraocular Pressure / drug effects* Macaca fascicularis Nitroglycerin / pharmacology* Vasodilator Agents / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
|
5T32 EY07097-02/EY/NEI NIH HHS; EY05077/EY/NEI NIH HHS; EY07321/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Vasodilator Agents; 55-63-0/Nitroglycerin; 86-54-4/Hydralazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neuron-specific enolase expression during eye development in the chicken embryo.
Next Document: Plasma lipid changes in PRCD-affected and normal miniature poodles given oral supplements of linseed...