Document Detail


Nitrovasodilator effects on intraocular pressure and outflow facility in monkeys.
MedLine Citation:
PMID:  8157106     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The nitrovasodilators nitroglycerin (NTG) and hydralazine (HZN) were investigated for their effects on intraocular pressure (IOP) and outflow facility in the cynomolgus monkey eye in vivo. Fifty microliters of 0.1% HZN were administered topically in masked, randomized, crossover, placebo controlled trials, and by intracameral perfusion. Both NTG and HZN decreased IOP (mean IOP decrease with NTG 4.40 +/- 2.11 (S.E.M.) (+/- 4.7, S.D.) mmHg, P < 0.01, n = 5, with HZN 3.15 +/- 0.85 (S.E.M.) (+/- 2.3, S.D.) mmHg, P = 0.01, n = 7). Outflow facility increased by 92% (P < 0.05) after intracameral bolus injection of 10(-3) mol l-1 NTG, but not at lower doses. Intracameral HZN caused a significant increase in facility of outflow of 28% (P < 0.05) when perfused at a constant concentration of 10(-5) mol l-1, but not at certain other concentrations. These results demonstrate the capacity for topically applied NTG and HZN to reduce IOP in the living primate eye. They further suggest that, at certain drug doses, but not others, the IOP reduction may be mediated, in part, by an action on the outflow apparatus.
Authors:
J S Schuman; K Erickson; J A Nathanson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Experimental eye research     Volume:  58     ISSN:  0014-4835     ISO Abbreviation:  Exp. Eye Res.     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-05-19     Completed Date:  1994-05-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370707     Medline TA:  Exp Eye Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  99-105     Citation Subset:  IM    
Affiliation:
New England Eye Center, Tufts University School of Medicine, Boston, MA 02111.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aqueous Humor / drug effects*
Depression, Chemical
Dose-Response Relationship, Drug
Female
Hydralazine / pharmacology*
Intraocular Pressure / drug effects*
Macaca fascicularis
Nitroglycerin / pharmacology*
Vasodilator Agents / pharmacology*
Grant Support
ID/Acronym/Agency:
5T32 EY07097-02/EY/NEI NIH HHS; EY05077/EY/NEI NIH HHS; EY07321/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 55-63-0/Nitroglycerin; 86-54-4/Hydralazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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