| Nitrous oxide, an opioid addictive agent. Review of the evidence. | |
MedLine Citation:
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PMID: 3014879 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pharmacologic evidence that nitrous oxide is addictive through direct interaction with the endogenous opioid system includes the possibility that it is a partial agonist and acts at the mu, kappa, and sigma opioid receptors. The medical and psychiatric complications of its abuse are discussed with special reference to the 32 cases of myeloneuropathy so far reported; other dangers are also mentioned. Notwithstanding the extremely low incidence of reported cases of nitrous oxide addiction compared with all other addictive substances, greater controls should be placed on its commercial availability to at least maintain its low level of abuse. |
Authors:
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M A Gillman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: The American journal of medicine Volume: 81 ISSN: 0002-9343 ISO Abbreviation: Am. J. Med. Publication Date: 1986 Jul |
Date Detail:
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Created Date: 1986-08-19 Completed Date: 1986-08-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0267200 Medline TA: Am J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 97-102 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesia Animals Drug Tolerance Humans Locomotion / drug effects Nervous System Diseases / chemically induced Nitrous Oxide* / pharmacology Opioid-Related Disorders* Radioligand Assay Receptors, Opioid / metabolism Substance-Related Disorders* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Opioid; 10024-97-2/Nitrous Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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