Document Detail

Nitrous oxide, an opioid addictive agent. Review of the evidence.
MedLine Citation:
PMID:  3014879     Owner:  NLM     Status:  MEDLINE    
Pharmacologic evidence that nitrous oxide is addictive through direct interaction with the endogenous opioid system includes the possibility that it is a partial agonist and acts at the mu, kappa, and sigma opioid receptors. The medical and psychiatric complications of its abuse are discussed with special reference to the 32 cases of myeloneuropathy so far reported; other dangers are also mentioned. Notwithstanding the extremely low incidence of reported cases of nitrous oxide addiction compared with all other addictive substances, greater controls should be placed on its commercial availability to at least maintain its low level of abuse.
M A Gillman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The American journal of medicine     Volume:  81     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1986-08-19     Completed Date:  1986-08-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  97-102     Citation Subset:  AIM; IM    
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MeSH Terms
Drug Tolerance
Locomotion / drug effects
Nervous System Diseases / chemically induced
Nitrous Oxide* / pharmacology
Opioid-Related Disorders*
Radioligand Assay
Receptors, Opioid / metabolism
Substance-Related Disorders*
Reg. No./Substance:
0/Receptors, Opioid; 10024-97-2/Nitrous Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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