| Nitrous oxide-induced hypothermia in the rat: acute and chronic tolerance. | |
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MedLine Citation:
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PMID: 9972863 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although inhalation of nitrous oxide (N2O) causes hypothermia in rats, there is a paucity of information as to whether tolerance develops to this effect. The purpose of this study was to determine whether tolerance to N2O hypothermia develops within a single administration as well as over repeated administrations. Temperature was measured telemetrically by implanting intraperitoneal thermal sensors/transmitters in male Long-Evans rats. Experimental rats received an initial 2-h exposure to 60% N2O and became hypothermic relative to controls breathing placebo gas. Only a few rats demonstrated evidence of acute tolerance over the 120 min. Over the next 10 days, the experimental rats received five additional 30-min exposures to 60% N2O and five 30-min exposures to placebo while the control rats received only placebo gas exposures. Chronic tolerance developed to N2O hypothermia over these repeated administrations. A test for Pavlovian drug conditioning found no evidence that conditioned temperature effects contributed to chronic tolerance development. In a second experiment, naive rats were given a 380-min exposure to 60% N2O and a 380-min exposure to placebo gas in a counterbalanced order. Acute tolerance did develop to N2O hypothermia, with the recovery of temperature beginning after a mean of 141 min of gas administration. Hence, both acute and chronic tolerance develop to N2O's hypothermic effects in rats. |
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Authors:
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D S Ramsay; K Omachi; B G Leroux; R J Seeley; C W Prall; S C Woods |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 62 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1999 Jan |
Date Detail:
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Created Date: 1999-04-13 Completed Date: 1999-04-13 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 189-96 Citation Subset: IM |
Affiliation:
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Department of Pediatric Dentistry, University of Washington, Seattle 98195-7136, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Anesthetics, Inhalation / administration & dosage, pharmacology* Animals Body Temperature / drug effects Conditioning, Classical / drug effects Drug Tolerance Hypothermia / chemically induced*, physiopathology Male Nitrous Oxide / administration & dosage, pharmacology* Rats Rats, Long-Evans |
| Grant Support | |
ID/Acronym/Agency:
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DA07391/DA/NIDA NIH HHS; DE00379/DE/NIDCR NIH HHS; DE09743/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Inhalation; 10024-97-2/Nitrous Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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