Document Detail

Nitrous oxide availability.
MedLine Citation:
PMID:  7381032     Owner:  NLM     Status:  MEDLINE    
Nitrous oxide (N2O) is marketed as an inhalation anesthetic and as a food ingredient (e.g., whipping cream propellant). In the human, inhalation has been associated with "highs," peripheral nerve damage, mitotic poisoning of bone marrow, psychosis, and mental impairment. Exposure to hypoxemic mixtures has resulted in death. The commercial N2O sources specifically studied were aerosol whipping cream containers (three brands) and 6.5-cm cylinders, or chargers (two brands). The gas content and N2O concentrations of these devices were measured. The aerosol cans, when not shaken, will dispense at least 3 liters of 87 to 90% N2O. Charger misuse may occur when they are substituted for identically designed carbon dioxide (CO2) chargers of a seltzer bottle; 4.3 to 5.0 liters of 93 to 98% N2O is expelled at a controllable rate. The toxicity of these inexpensive N2O products, their high potential for misuse, and the absence of labeling (chargers) argue that their distribution be discontinued.
M J Murray; W J Murray
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical pharmacology     Volume:  20     ISSN:  0091-2700     ISO Abbreviation:  J Clin Pharmacol     Publication Date:  1980 Apr 
Date Detail:
Created Date:  1980-08-15     Completed Date:  1980-08-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0366372     Medline TA:  J Clin Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  202-5     Citation Subset:  IM    
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MeSH Terms
Drug Labeling
Household Products
Nitrous Oxide / supply & distribution*
Substance-Related Disorders / epidemiology*
United States
Reg. No./Substance:
0/Aerosols; 10024-97-2/Nitrous Oxide

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