Document Detail


Nitrotyrosine in human neonatal spinal cord after perinatal asphyxia.
MedLine Citation:
PMID:  17652956     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Spinal cord injury has been reported after perinatal asphyxia in full-term neonates. OBJECTIVES: To examine the role of excessive nitric oxide production in perinatal spinal cord injury. SUBJECTS AND METHODS: Tissue samples of 18 full-term neonates who died of hypoxic-ischemic encephalopathy were analyzed for the presence of nitrotyrosine (NT). RESULTS: NT was demonstrated in 5 of these 18 neonates. In addition, activated caspase 3, a marker of apoptosis, and CD68, as a marker of inflammation, could be demonstrated in some infants. CONCLUSIONS: excessive nitric oxide production and subsequent NT formation is seen in spinal cord tissue after severe perinatal asphyxia. This finding may be relevant for the development of neuroprotective strategies.
Authors:
Floris Groenendaal; Johannes Vles; Harry Lammers; Jan De Vente; Diane Smit; Peter G J Nikkels
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-07-25
Journal Detail:
Title:  Neonatology     Volume:  93     ISSN:  1661-7819     ISO Abbreviation:  -     Publication Date:  2008  
Date Detail:
Created Date:  2007-12-18     Completed Date:  2008-01-23     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  101286577     Medline TA:  Neonatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2007 S. Karger AG, Basel.
Affiliation:
Department of Neonatology, University Medical Center Utrecht, Utrecht, The Netherlands. F.Groenendaal@umcutrecht.nl
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD / metabolism
Antigens, Differentiation, Myelomonocytic / metabolism
Apoptosis
Asphyxia Neonatorum / metabolism*,  pathology
Autopsy
Caspase 3 / metabolism
Female
Humans
Hypoxia-Ischemia, Brain
Infant, Newborn
Inflammation
Male
Nitric Oxide / metabolism*
Spinal Cord / metabolism*,  pathology
Tyrosine / analogs & derivatives*,  metabolism
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, Differentiation, Myelomonocytic; 0/CD68 antigen, human; 10102-43-9/Nitric Oxide; 3604-79-3/3-nitrotyrosine; 55520-40-6/Tyrosine; EC 3.4.22.-/Caspase 3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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