| Nitrosative stress causes amino acid auxotrophy in hmp mutant Salmonella Typhimurium. | |
| | |
MedLine Citation:
|
PMID: 21752086 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Cytotoxic nitic oxide (NO) damages various bacterial macromolecules, resulting in abnormal metabolism by mechanisms largely unknown. We show that NO can cause amino acid auxotrophy in Salmonella Typhimurium lacking major NO-metabolizing enzyme, Flavohemoglobin Hmp. In NO-producing cultures, supplementation with amino acid pool restores growth of Hmp-deficient Salmonella to normal growth phases, whereas excluding Cys or branched-chain amino acids (BCAA) Leu, Ile, or Val from amino acid pool reduces growth recovery. Data suggest that, without detoxification, NO might inactivate key enzymes in the biosynthesis pathway of amino acids essential for Salmonella replication in amino acid-limiting host environments. |
| | |
Authors:
|
Yoon Mee Park; Hee Jeong Park; Young Hee Joung; Iel Soo Bang |
Related Documents
:
|
9117886 - Characterization of the 33-kilodalton major allergen of penicillium citrinum by using m... 15194706 - The role of the length and sequence of the linker domain of cytochrome b5 in stimulatin... 17373556 - Identification of a single and non-essential cysteine residue in dextransucrase of leuc... 16434446 - Proteomecommons.org jaf: reference information and tools for proteomics. 3312186 - Involvement of the fatty acid oxidation complex in acetyl-coa-dependent chain elongatio... 10380116 - 3-thia fatty acid treatment, in contrast to eicosapentaenoic acid and starvation, induc... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-7-13 |
Journal Detail:
|
Title: Microbiology and immunology Volume: - ISSN: 1348-0421 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-7-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7703966 Medline TA: Microbiol Immunol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 The Societies and Blackwell Publishing Asia Pty Ltd. |
Affiliation:
|
Department of Microbiology and Immunology, Chosun University School of Dentistry, Gwangju 501-759 School of Biological Sciences and Technology, Chonnam National University, Gwangju 500-757, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genotypes of rotavirus associated with acute gastroenteritis in Seoul, Korea.
Next Document: Modulation of poly-N-acetylglucosamine accumulation within mature Staphylococcus epidermidis biofilm...