Document Detail


Nitroprusside-induced hemodynamic alterations in normotensive and hypertensive pregnant sheep.
MedLine Citation:
PMID:  7223793     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been suggested that sodium nitroprusside, a potent vasodilator, be used in the management of an acute hypertensive crisis during pregnancy. The present study was designed to evaluate the hemodynamic effects of this agent in the same group of chronically instrumented, unanesthetized pregnant sheep during two experimental periods: (a) normotension with intact kidneys, and (b) one-kidney hypertension. The results demonstrate that (1) nitroprusside is a potent vasodilator which lowers mean arterial pressure; (2) nitroprusside-induced tachycardia was greater in the hypertensive animal; (3) uterine blood flow decreased with the development of hypertension; (4) the hypertensive-induced reduction in uterine blood flow was increased by the infusion of nitroprusside.
Authors:
S M Lieb; M Zugaib; B Nuwayhid; K Tabsh; R Erkkola; E Ushioda; C R Brinkman; N S Assali
Related Documents :
22262923 - Differential cardiorespiratory and sympathetic reflex responses to microinjection of ne...
9931083 - Ultrasonic myocardial texture versus doppler analysis in hypertensive heart: a prelimin...
3139443 - The oxygen environment of the arterial media in early rabbit hypertension.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  139     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1981 Apr 
Date Detail:
Created Date:  1981-06-13     Completed Date:  1981-06-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  925-31     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blood Circulation / drug effects
Blood Pressure / drug effects
Female
Ferricyanides / pharmacology*
Heart Rate / drug effects
Hemodynamics / drug effects*
Hypertension / physiopathology*
Kidney / blood supply
Nitroprusside / pharmacology*
Pregnancy
Pregnancy Complications, Cardiovascular / physiopathology*
Sheep
Uterus / blood supply
Chemical
Reg. No./Substance:
0/Ferricyanides; 15078-28-1/Nitroprusside

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Increased gentamicin dosage requirements: rapid elimination in 249 gynecology patients.
Next Document:  Phosphoenolpyruvate carboxykinase activity in human amniotic fluid.