Document Detail

Nitroprusside-induced hemodynamic alterations in normotensive and hypertensive pregnant sheep.
MedLine Citation:
PMID:  7223793     Owner:  NLM     Status:  MEDLINE    
It has been suggested that sodium nitroprusside, a potent vasodilator, be used in the management of an acute hypertensive crisis during pregnancy. The present study was designed to evaluate the hemodynamic effects of this agent in the same group of chronically instrumented, unanesthetized pregnant sheep during two experimental periods: (a) normotension with intact kidneys, and (b) one-kidney hypertension. The results demonstrate that (1) nitroprusside is a potent vasodilator which lowers mean arterial pressure; (2) nitroprusside-induced tachycardia was greater in the hypertensive animal; (3) uterine blood flow decreased with the development of hypertension; (4) the hypertensive-induced reduction in uterine blood flow was increased by the infusion of nitroprusside.
S M Lieb; M Zugaib; B Nuwayhid; K Tabsh; R Erkkola; E Ushioda; C R Brinkman; N S Assali
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  139     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1981 Apr 
Date Detail:
Created Date:  1981-06-13     Completed Date:  1981-06-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  925-31     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Circulation / drug effects
Blood Pressure / drug effects
Ferricyanides / pharmacology*
Heart Rate / drug effects
Hemodynamics / drug effects*
Hypertension / physiopathology*
Kidney / blood supply
Nitroprusside / pharmacology*
Pregnancy Complications, Cardiovascular / physiopathology*
Uterus / blood supply
Reg. No./Substance:
0/Ferricyanides; 15078-28-1/Nitroprusside

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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