| Nitroprusside-induced hemodynamic alterations in normotensive and hypertensive pregnant sheep. | |
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MedLine Citation:
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PMID: 7223793 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been suggested that sodium nitroprusside, a potent vasodilator, be used in the management of an acute hypertensive crisis during pregnancy. The present study was designed to evaluate the hemodynamic effects of this agent in the same group of chronically instrumented, unanesthetized pregnant sheep during two experimental periods: (a) normotension with intact kidneys, and (b) one-kidney hypertension. The results demonstrate that (1) nitroprusside is a potent vasodilator which lowers mean arterial pressure; (2) nitroprusside-induced tachycardia was greater in the hypertensive animal; (3) uterine blood flow decreased with the development of hypertension; (4) the hypertensive-induced reduction in uterine blood flow was increased by the infusion of nitroprusside. |
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Authors:
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S M Lieb; M Zugaib; B Nuwayhid; K Tabsh; R Erkkola; E Ushioda; C R Brinkman; N S Assali |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 139 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1981 Apr |
Date Detail:
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Created Date: 1981-06-13 Completed Date: 1981-06-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 925-31 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Circulation / drug effects Blood Pressure / drug effects Female Ferricyanides / pharmacology* Heart Rate / drug effects Hemodynamics / drug effects* Hypertension / physiopathology* Kidney / blood supply Nitroprusside / pharmacology* Pregnancy Pregnancy Complications, Cardiovascular / physiopathology* Sheep Uterus / blood supply |
| Chemical | |
Reg. No./Substance:
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0/Ferricyanides; 15078-28-1/Nitroprusside |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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