Document Detail

Nitroprusside in children after cardiopulmonary bypass: a study of thiocyanate toxicity.
MedLine Citation:
PMID:  2798186     Owner:  NLM     Status:  MEDLINE    
Thiocyanate levels, an indicator of nitroprusside toxicity, were studied in 22 children after repair of structural heart disease during cardiopulmonary bypass. At the total dose (2.6 +/- 2.3 mg/kg) and time (34.4 +/- 19 h) ranges of this study, no evidence of toxicity was detected, despite this total dose exceeding recommended maximum in some patients. Nitroprusside infusion, as described, in children with normal hepatic and renal function is safe and may not warrant routine assessment of thiocyanate levels.
S Kunathai; G F Sholler; J M Celermajer; M O'Halloran; T B Cartmill; G R Nunn
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric cardiology     Volume:  10     ISSN:  0172-0643     ISO Abbreviation:  Pediatr Cardiol     Publication Date:  1989  
Date Detail:
Created Date:  1989-11-07     Completed Date:  1989-11-07     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  121-4     Citation Subset:  IM    
Adolph Basser Institute of Cardiology, Children's Hospital, Camperdown, Sydney, Australia.
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MeSH Terms
Aspartate Aminotransferases / blood
Cardiopulmonary Bypass*
Child, Preschool
Ferricyanides / therapeutic use*
Nitroprusside / adverse effects,  therapeutic use*
Postoperative Care
Thiocyanates / blood*
Urea / blood
Reg. No./Substance:
0/Ferricyanides; 0/Thiocyanates; 15078-28-1/Nitroprusside; 302-04-5/thiocyanate; 57-13-6/Urea; EC Aminotransferases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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