Document Detail


Nitroglycerin does not alter pulmonary vascular permeability in isolated rabbit lungs.
MedLine Citation:
PMID:  9024029     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nitroglycerin (NTG) produces vasodilation by releasing nitric oxide (NO) at the cellular level. Other studies have suggested that NO may directly alter vascular permeability and may alter the development of tissue injury. We therefore examined the effects of NTG on vascular permeability in the buffer-perfused rabbit lung under normal conditions and during lung injury. Vascular permeability was assessed by measurement of the capillary filtration coefficient (Kf,c). In normal lungs, NTG did not alter Kf,c or the rate of weight gain. Oxidant lung injury was produced by the addition of purine and xanthine oxidase and resulted in increased Kf,c and increased weight gain. However, NTG did not alter these effects of oxidant lung injury. We conclude that NTG does not alter pulmonary vascular permeability in either normal or oxidant-injured lungs.
Authors:
J S Thompson; B P Kavanagh; R G Pearl
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  84     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-03-04     Completed Date:  1997-03-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  359-62     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesia, Stanford University Medical Center, CA 94305-5117, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Capillary Permeability / drug effects*
Lung / blood supply*,  pathology
Male
Nitroglycerin / pharmacology*
Organ Size
Oxidants
Rabbits
Respiratory Distress Syndrome, Adult / chemically induced,  physiopathology
Vasodilator Agents / pharmacology*
Chemical
Reg. No./Substance:
0/Oxidants; 0/Vasodilator Agents; 55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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