| Nitroglycerin combined with methoxamine in experimental coronary occlusions. | |
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MedLine Citation:
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PMID: 6814818 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of nitroglycerin, methoxamine, and the combination of both drugs were studied in anaesthetized dogs, during the acute phase of experimental myocardial infarction. Different haemodynamic and electrophysiological parameters were measured during the first three minutes of occluding the left descending coronary artery, while each drug or the combination were being infused. After stopping infusions, new occlusions were performed periodically in order to assess the persistence of drug effects. Nitroglycerin alone provoked hypotension and reduced the development of the ischaemic area, while methoxamine did not modify the measured variables. A long-lasting favourable effect on the ischaemic area was recorded when methoxamine prevented hypotension induced by nitroglycerin. |
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Authors:
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T Pérez Medina; E Udváry; L Szekeres |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cor et vasa Volume: 24 ISSN: 0010-8650 ISO Abbreviation: Cor Vasa Publication Date: 1982 |
Date Detail:
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Created Date: 1983-01-07 Completed Date: 1983-01-07 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372614 Medline TA: Cor Vasa Country: CZECHOSLOVAKIA |
Other Details:
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Languages: eng Pagination: 287-94 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dogs Drug Therapy, Combination Female Male Methoxamine / administration & dosage*, pharmacology Myocardial Infarction / drug therapy*, physiopathology Nitroglycerin / administration & dosage*, pharmacology |
| Chemical | |
Reg. No./Substance:
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390-28-3/Methoxamine; 55-63-0/Nitroglycerin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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