Document Detail

Nitroglycerin as a hypotensive drug during general anesthesia.
MedLine Citation:
PMID:  96706     Owner:  NLM     Status:  MEDLINE    
Circulatory variables and arterial partial pressure for oxygen (PaO2) were compared in 91 anesthetized patients who received infusions of either nitroglycerin (TNG) or nitroprusside (SNP) to induce hypotension for the purpose of decreasing intraoperative blood loss. At comparable systolic arterial blood pressures, the mean and diastolic arterial blood pressures were significantly higher with TNG. Electrocardiographic changes suggestive of ischemia occurred in 18 patients who received SNP, whereas none were detected in patients given TNG. Both drugs significantly decreased PaO2 and rate-pressure product, an indirect index of myocardial oxygen consumption. No untoward response to TNG occurred. No clinical evidence of myocardial infarction, renal damage, or cerebral vascular complication was encountered in the postoperative period in any patient. Thus, TNG is an effective hypotensive drug that may prove superior to currently available agents.
N R Fahmy
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Anesthesiology     Volume:  49     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1978 Jul 
Date Detail:
Created Date:  1978-09-01     Completed Date:  1978-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  17-20     Citation Subset:  AIM; IM    
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MeSH Terms
Anesthesia, Inhalation*
Blood Pressure / drug effects*
Carbon Dioxide / blood
Hypotension, Controlled*
Middle Aged
Nitroglycerin / pharmacology*
Nitroprusside / pharmacology
Nitrous Oxide
Oxygen / blood
Oxygen Consumption / drug effects
Partial Pressure
Reg. No./Substance:
10024-97-2/Nitrous Oxide; 124-38-9/Carbon Dioxide; 15078-28-1/Nitroprusside; 151-67-7/Halothane; 55-63-0/Nitroglycerin; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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