| Nitroglycerin and epinephrine improve coronary perfusion pressure in a porcine model of ventricular fibrillation arrest: a pilot study. | |
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MedLine Citation:
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PMID: 19097731 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Cardiac arrest remains one of the leading causes of death worldwide. European Resuscitation Council Guidelines for Resuscitation 2005 recommend epinephrine for its treatment. OBJECTIVES: To estimate whether the administration of a vasodilatator such as nitroglycerin in combination with epinephrine during cardiopulmonary resuscitation would improve resuscitation outcome in an established model of ventricular fibrillation. METHODS: Design: Prospective, randomized, blinded, controlled study. Setting: Animal research laboratory. Ventricular fibrillation was induced in 20 Landrace/Large-White pigs. It remained untreated for 8 min before attempting resuscitation precordial compressions, mechanical ventilation, and electrical defibrillation. Animals were randomized into two groups, 10 animals each. Group A received saline as placebo (10 mL dilution, bolus) and epinephrine (0.02 mg/kg). Group B received nitroglycerin (50 microg/kg) and epinephrine (0.02 mg/kg) during cardiopulmonary resuscitation. Electrical defibrillation was attempted after 10 min of ventricular fibrillation. RESULTS: Four animals in group A restored spontaneous circulation in comparison to eight in Group B. Coronary perfusion pressure (p < 0.0001) was significantly increased in Group B during cardiopulmonary resuscitation. CONCLUSION: A vasodilatator, when administered in combination with a vasopressor such as epinephrine during cardiopulmonary resuscitation, increases coronary perfusion pressure. |
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Authors:
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Vassiliki Kitsou; Theodoros Xanthos; Konstantinos Stroumpoulis; George Rokas; Dimitrios Papadimitriou; Ioannis Serpetinis; Ismene Dontas; Despina Perrea; Evangelia Kouskouni |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-12-20 |
Journal Detail:
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Title: The Journal of emergency medicine Volume: 37 ISSN: 0736-4679 ISO Abbreviation: J Emerg Med Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8412174 Medline TA: J Emerg Med Country: United States |
Other Details:
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Languages: eng Pagination: 369-75 Citation Subset: IM |
Affiliation:
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Department of Experimental Surgery and Surgical Research, Medical School, University of Athens, Athens 11527, Greece. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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