Document Detail

Nitrogen sparing induced early in starvation by infusion of branched-chain ketoacids.
MedLine Citation:
PMID:  834156     Owner:  NLM     Status:  MEDLINE    
The alpha-ketoanalogues of the branched-chain amino acids were administered to fasting subjects to determine whether or not they promoted nitrogen sparing. Two fasting studies were carried out in each subject. During the first week of one of the two fasts 4.7 g of a mixture of the alpha-ketoanalogues of valine, leucine, and isoleucine were infused daily. No infusions were administered during the other fast, which served as a control. Urinary urea and calculated total urinary nitrogen were significantly lower during both the week of infusions and the ensuing week of fasting after the infusions were discontinued. Immediately after ketoacid infusions, plasma branched-chain amino acids, including allosioleucine, rose, while alanine and several other amino acids (but not glutamine) fell. There were no differences between the two fasts with respect to ketone bodies, free fatty acids, glucose, insulin, or glucagon concentrations. We conclude that branched-chain ketoacids spare nitrogen early in fasting and that this effect persists after they are metabolized.
D G Sapir; M Walser
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  26     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1977 Mar 
Date Detail:
Created Date:  1977-03-31     Completed Date:  1977-03-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  301-8     Citation Subset:  IM    
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MeSH Terms
Amino Acids / blood
Creatinine / urine
Keto Acids / metabolism*,  pharmacology
Nitrogen / metabolism*
Obesity / diet therapy
Quaternary Ammonium Compounds / urine
Starvation / metabolism*
Urea / urine
Uric Acid / urine
Reg. No./Substance:
0/Amino Acids; 0/Keto Acids; 0/Quaternary Ammonium Compounds; 57-13-6/Urea; 60-27-5/Creatinine; 69-93-2/Uric Acid; 7727-37-9/Nitrogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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