Document Detail

Nitrogen retention in men fed isolated soybean protein supplemented with L-methionine, D-methionine, N-acetyl-L-methionine, or inorganic sulfate.
MedLine Citation:
PMID:  986424     Owner:  NLM     Status:  MEDLINE    
The ability of various sulfur-containing compounds to replace L-methionine (L-Met) was investigated by metabolic balance studies in man. N-acetyl-L-Methionine (AcMet), D-methionine (D-Met), and sodium sulfate (Na2SO4) were used to supplement a diet deficient in sulfur amino acids. The daily diet contained 4.5 g nitrogen (N) from isolated soybean protein (SB) and 4.5 g from glycine and alanine (9 g total N). SB diet was given alone or supplemented to six adult men for periods of 9 days after a standardization period with an equal N eggwhite diet, preceded by a 2-day zero N adaptation period. Supplements provided equivalent amounts of sulfur to that present in 420 ml L-Met, the amount added to SB to bring the total sulfur amino acid content to 900 mg/day. AcMet was as benfeficial as L-Met in improving N balance but D-Met was not as effective as L-Met. Difference between balances obtained with L-Met and Na2SO4 was not significant due to large variation in response to Na2SO4. While addition of D-Met to SB did not result in significantly greater N retention than unsupplemented SB, NA2SO4 addition did cause increased N retention.
A Y Zezulka; D H Calloway
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of nutrition     Volume:  106     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1976 Sep 
Date Detail:
Created Date:  1976-10-20     Completed Date:  1976-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1286-91     Citation Subset:  IM    
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MeSH Terms
Amino Acids, Sulfur / deficiency
Dietary Proteins
Feces / analysis
Food, Fortified
Methionine* / analogs & derivatives*
Nitrogen / metabolism*
Vegetable Proteins* / metabolism
Reg. No./Substance:
0/Amino Acids, Sulfur; 0/Dietary Proteins; 0/Sulfates; 0/Vegetable Proteins; 63-68-3/Methionine; 7727-37-9/Nitrogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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