| Nitrogen metabolism in the perfused cirrhotic liver of the rat. | |
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MedLine Citation:
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PMID: 1113014 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The isolated perfused liver of the cirrhotic rat produces greater quantities of ammonia from endogenous sources or from added alanine than do control livers. It also fails to take up ammonia. In these cirrhotic livers ethanol increases ammonia production in the presence of alanine. When cirrhotic rats had received a normal diet for 10 days before perfusion, the output of ammonia from endogenous sources and from added alanine is partially restored to normal. The addition of ethanol in the presence of alanine to the perfusate of these cirrhotic livers then results in an increased rate of production of glutamine rather than of ammonia. A normal diet given these cirrhotic animals restores the uptake of ammonia to that seen in the control animals but, unlike the normal animals, the addition of ornithine increases neither the uptake of ammonia nor the output of urea. In the normal animals this effect of ornithine on the uptake of ammonia is abolished by ethanol. It is concluded that cirrhotic rat liver is a source of endogenous ammonia and that the magnitude of that contribution is modified by diet and by ethanol. |
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Authors:
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K S Henley; P E Clancy; E G Laughrey; L G Lyra |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of laboratory and clinical medicine Volume: 85 ISSN: 0022-2143 ISO Abbreviation: J. Lab. Clin. Med. Publication Date: 1975 Feb |
Date Detail:
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Created Date: 1975-05-19 Completed Date: 1975-05-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375375 Medline TA: J Lab Clin Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 273-80 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alanine
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metabolism Ammonia / metabolism Animals Diet Ethanol / pharmacology Glucose / metabolism Glutamates / metabolism Glutamine / biosynthesis Liver / anatomy & histology, metabolism Liver Cirrhosis, Experimental / metabolism* Male Nitrogen / metabolism* Organ Size Ornithine / pharmacology Perfusion Rats Urea / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Glutamates; 50-99-7/Glucose; 56-41-7/Alanine; 56-85-9/Glutamine; 57-13-6/Urea; 64-17-5/Ethanol; 7006-33-9/Ornithine; 7664-41-7/Ammonia; 7727-37-9/Nitrogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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