| Nitrogen metabolism and growth in experimental uremia. | |
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MedLine Citation:
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PMID: 7343527 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Growth in length, weight gain and gain of body nitrogen were compared in rats with stable long-term uremia (U) resulting from subtotal two-stage nephrectomy with irradiation of residual parenchyma, in sham-operated pair-fed control rats (PFC) and in ad libitum fed control rats (LC). Growth in length and weight gain were considerably lower in U than in LC rats, reflecting mainly diminished intake of food in uremia. However, they were also significantly lower in U than in PFC despite identical intake of food, pointing to a specific adverse effect of uremia on growth. Whole body dry matter, whole body nitrogen and weight of a reference muscle (triceps surae) were significantly lower in U than in PFC animals, showing that dietary nitrogen and/or energy are less efficiently utilized for protein synthesis in U animals. Diminished net nitrogen retention was paralleled by increased urinary nitrogen loss (excretion of urea, alpha-amino nitrogen, protein, and creatinine). Within the precision of the method used, no significant difference of oxygen consumption between U and PFC animals could be demonstrated. The plasma amino acid pattern was deranged and the tyrosine/phenylalanine ratio was decreased despite no change in hepatic phenylalanine hydroxylase. The findings document increased nitrogen and/or energy cost of growth in rats with stable chronic uremia; this finding agrees with previous observations of disturbed protein metabolism and hypercatabolism in experimental uremia. |
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Authors:
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O Mehls; E Ritz; G Gilli; K Bartholomé; H Beissbarth; M Hohenegger; W Schafnitzel |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The International journal of pediatric nephrology Volume: 1 ISSN: 0391-6510 ISO Abbreviation: Int J Pediatr Nephrol Publication Date: 1980 Mar |
Date Detail:
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Created Date: 1982-08-14 Completed Date: 1982-08-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8007162 Medline TA: Int J Pediatr Nephrol Country: ITALY |
Other Details:
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Languages: eng Pagination: 34-41 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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blood Animals Biometry Body Weight Growth* Male Nitrogen / analysis, metabolism* Rats Rats, Inbred Strains Uremia / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 7727-37-9/Nitrogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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