Document Detail

Nitrogen flux across ovine maternal and fetal hindquarters during fasting.
MedLine Citation:
PMID:  3598149     Owner:  NLM     Status:  MEDLINE    
Nitrogen flux across the hindquarters of fetal and maternal sheep (n = 15) was determined during normal feeding and following 5 days of maternal fasting. Arterial and venous whole blood concentrations of free amino acids, ammonia and oxygen were measured entering and exiting the hindquarters. Further, the DNA, protein and nitrogen contents of the hindlimb skeletal muscle of the fetus were determined in the fed state and following the 5-day fast. Results of these studies indicate that maternal and fetal hindlimb metabolism differ during fasting. There is a net efflux of alanine, glutamine and total nitrogen from the maternal hindquarters following 5 days of fasting. The fetus also releases glutamine and alanine from the hindquarters during the fast, presumably as potential energy substrate. However, nitrogen balance across the fetal hindquarter remains positive as a result of increased positive arteriovenous differences for other amino acids (particularly leucine and isoleucine). The concentrations of DNA, protein and nitrogen in fetal skeletal muscle remain unchanged during fasting. These data indicate that, whereas the mother undergoes protein catabolism and net nitrogen loss from the hindquarter during fasting, the fetus maintains a positive nitrogen balance across the hindquarter.
J A Lemons; E A Liechty
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of developmental physiology     Volume:  9     ISSN:  0141-9846     ISO Abbreviation:  J. Dev. Physiol.     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-08-04     Completed Date:  1987-08-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7910737     Medline TA:  J Dev Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  151-8     Citation Subset:  IM    
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MeSH Terms
Amino Acids / blood
Hindlimb / metabolism
Maternal-Fetal Exchange*
Muscles / metabolism
Nitrogen / metabolism*
Oxygen / metabolism
Grant Support
R01-14820-05//PHS HHS
Reg. No./Substance:
0/Amino Acids; 7727-37-9/Nitrogen; 7782-44-7/Oxygen

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