Document Detail

Nitrogen flux across ovine maternal and fetal hindquarters during fasting.
MedLine Citation:
PMID:  3598149     Owner:  NLM     Status:  MEDLINE    
Nitrogen flux across the hindquarters of fetal and maternal sheep (n = 15) was determined during normal feeding and following 5 days of maternal fasting. Arterial and venous whole blood concentrations of free amino acids, ammonia and oxygen were measured entering and exiting the hindquarters. Further, the DNA, protein and nitrogen contents of the hindlimb skeletal muscle of the fetus were determined in the fed state and following the 5-day fast. Results of these studies indicate that maternal and fetal hindlimb metabolism differ during fasting. There is a net efflux of alanine, glutamine and total nitrogen from the maternal hindquarters following 5 days of fasting. The fetus also releases glutamine and alanine from the hindquarters during the fast, presumably as potential energy substrate. However, nitrogen balance across the fetal hindquarter remains positive as a result of increased positive arteriovenous differences for other amino acids (particularly leucine and isoleucine). The concentrations of DNA, protein and nitrogen in fetal skeletal muscle remain unchanged during fasting. These data indicate that, whereas the mother undergoes protein catabolism and net nitrogen loss from the hindquarter during fasting, the fetus maintains a positive nitrogen balance across the hindquarter.
J A Lemons; E A Liechty
Related Documents :
24914509 - Dysregulation of hydrogen sulphide metabolism impairs oviductal transport of embryos.
17314279 - White matter plasticity and enhanced remyelination in the maternal cns.
8214159 - Increased uteroplacental production of prostaglandin e2 during ethanol infusion.
22580289 - Complex expression changes of the placental endothelin system in early and late onset p...
19559319 - The maternal side of maternal-fetal surgery.
2382159 - Can acetaminophen excess result in maternal and fetal toxicity?
7607749 - Stabilisation of rampant caries: polyol gums and arrest of dentine caries in two long-t...
21121869 - Managing the teratogenic risk of thalidomide and lenalidomide: an industry perspective.
14557009 - Do prophylactic prostaglandins reduce the transfusion rate at cesarean section in high-...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of developmental physiology     Volume:  9     ISSN:  0141-9846     ISO Abbreviation:  J. Dev. Physiol.     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-08-04     Completed Date:  1987-08-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7910737     Medline TA:  J Dev Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  151-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Amino Acids / blood
Hindlimb / metabolism
Maternal-Fetal Exchange*
Muscles / metabolism
Nitrogen / metabolism*
Oxygen / metabolism
Grant Support
R01-14820-05//PHS HHS
Reg. No./Substance:
0/Amino Acids; 7727-37-9/Nitrogen; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of restriction of placental growth on oxygen delivery to and consumption by the pregnant uter...
Next Document:  The pericardium and cardiac transmural filling pressure in the fetal sheep.