Document Detail

Nitrogen dioxide is not associated with respiratory infection during the first year of life.
MedLine Citation:
PMID:  15075156     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Nitrogen dioxide (NO(2)) has been related to respiratory infections in experimental studies but its role remains controversial in general population studies of children. We aim to assess the association between indoor NO(2) and lower respiratory tract infections (LRTI) during the first year of life in a multicentre prospective cohort study. METHODS: Children (n = 1611) were recruited prior to birth for the Asthma Multicentre Infants Cohort Study (AMICS). Three concurrent cohorts (Ashford, Kent [UK]; Barcelona city, and Menorca Island [Spain]) followed the same research protocol. NO(2) was measured with passive diffusion tubes placed in the living room for 2 weeks when infants were approximately 3 months old. Doctor-diagnosed LRTI during the first year of life (as well as antibiotic use) were measured by questionnaire, and in Ashford validated by the examination of clinical records. In Barcelona, direct measurements using nasopharyngeal lavage and cultures within a continuous surveillance system were done. RESULTS: The cumulative rates of LRTI (39% in Ashford, 28% in Barcelona, and 45% in Menorca) were unrelated to NO(2) levels (corresponding medians 6, 46, and 12 ppb, respectively) in all three centres (all odds ratios being around 1). Similarly, the rates of LRTI in Barcelona measured with the continuous record showed no association with NO(2) (all rate ratios being below 1). In addition, there was no association between rate of antibiotics courses per year per child (2.4 in Ashford, 1.7 in Barcelona, 0.9 in Menorca) and NO(2) levels. CONCLUSIONS: Indoor NO(2) at current levels does not seem to be involved in increasing respiratory infections by itself in infants, suggesting that the effects observed in studies on outdoor air are probably due to other copollutants.
Jordi Sunyer; Carme Puig; Maties Torrent; Oscar Garcia-Algar; Ignasi Calicó; Laura Muñoz-Ortiz; Maria Barnes; Paul Cullinan;
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  International journal of epidemiology     Volume:  33     ISSN:  0300-5771     ISO Abbreviation:  Int J Epidemiol     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-04-12     Completed Date:  2004-08-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7802871     Medline TA:  Int J Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  116-20     Citation Subset:  IM    
Unitat Recerca Respiratria i Ambietal, Institut Municipal Investigació Mèdica, Barcelona, Catalonia, Spain.
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MeSH Terms
Air Pollutants / analysis*
Air Pollution, Indoor / analysis*
England / epidemiology
Fossil Fuels / adverse effects
Household Articles
Nitrogen Dioxide / analysis*
Prospective Studies
Respiratory Tract Infections / epidemiology,  etiology*
Spain / epidemiology
Reg. No./Substance:
0/Air Pollutants; 0/Fossil Fuels; 10102-44-0/Nitrogen Dioxide

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