Document Detail

Nitrogen dioxide induced changes in level of free fatty acids, triglyceride, esterified fatty acid, ganglioside and lipase activity in the guinea pig brain.
MedLine Citation:
PMID:  1556389     Owner:  NLM     Status:  MEDLINE    
The biochemical response to controlled inhalation of nitrogen dioxide (NO2) was studied in 18 male guinea pigs. Animals were exposed to 2.5, 5.0, and 10 ppm NO2 for 2h daily for 35 consecutive days, and the results compared with six control animals exposed to filtered air for 2h daily for same period. Five biochemical parameters, including triglyceride, free fatty acids, esterified fatty acid, ganglioside and lipase activity were measured immediately after the last day of exposure. At 2.5 ppm NO2 inhalation no significant changes occurred in any region of the central nervous system (CNS). While as the dose concentration was increased to 5 and 10 ppm nitrogen dioxide, significant dose-related alteration were observed in the levels of triglyceride, free fatty acid, esterified fatty acid, ganglioside and lipase activity in the different regions of the guinea pig CNS.
H Farahani; M Hasan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes     Volume:  27     ISSN:  0360-1234     ISO Abbreviation:  J Environ Sci Health B     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-05-05     Completed Date:  1992-05-05     Revised Date:  2009-07-21    
Medline Journal Info:
Nlm Unique ID:  7607167     Medline TA:  J Environ Sci Health B     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  53-71     Citation Subset:  IM    
Interdisciplinary Brain Research Centre, Jawaharlal Nehru Medical College, Aligarh Muslim University, India.
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MeSH Terms
Administration, Inhalation
Air Pollutants / toxicity
Brain / enzymology
Brain Chemistry / drug effects*
Cerebellum / chemistry,  drug effects
Dose-Response Relationship, Drug
Environmental Exposure
Fatty Acids / analysis
Fatty Acids, Nonesterified / analysis
Gangliosides / analysis*
Guinea Pigs
Lipase / analysis*
Lipids / analysis*
Mesencephalon / chemistry,  drug effects
Nitrogen Dioxide / administration & dosage,  toxicity*
Spinal Cord / chemistry,  drug effects
Triglycerides / analysis
Reg. No./Substance:
0/Air Pollutants; 0/Fatty Acids; 0/Fatty Acids, Nonesterified; 0/Gangliosides; 0/Lipids; 0/Triglycerides; 10102-44-0/Nitrogen Dioxide; EC

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