Document Detail

Nitrogen balance and protein turnover during the growth failure in newly born low-birth-weight infants.
MedLine Citation:
PMID:  2035469     Owner:  NLM     Status:  MEDLINE    
Weight gain, nitrogen balance, protein turnover, and energy and protein intakes were measured during the first week of life of 14 low-birth-weight (LBW) infants, 5 small-for-gestational-age (SGA) infants and 9 appropriate-for-gestational-age (AGA) infants enterally fed at rates determined by the infants ability to assimilate feed. Mean gross intakes were 334 KJ and 1.75 g/kg protein; 4 infants were increasing and 10 were losing weight at rates proportional to gross energy and protein intakes and to nitrogen balance (0.031 g protein balance/g wt gain). Rates of protein synthesis and degradation measured by an intragastric infusion of [1-13C]leucine, averaged 14.5 and 15.9 g, some 50% higher than previously reported in older preterm infants and not correlated with nitrogen balance. The growth failure of these infants was not associated with inadequate overall rates of protein turnover, but appeared to reflect an influence of the insufficient energy and protein intakes on the high rates of protein turnover, inducing changes in protein balance in either direction through relatively small changes in protein synthesis and/or degradation.
H Kandil; O Darwish; S Hammad; N Zagloul; D Halliday; J Millward
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  53     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-06-21     Completed Date:  1991-06-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1411-7     Citation Subset:  AIM; IM    
High Institute of Public Health, University of Alexandria, Egypt.
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MeSH Terms
Dietary Proteins / administration & dosage
Energy Intake
Infant, Low Birth Weight / growth & development*
Infant, Newborn
Infant, Premature / growth & development*
Infant, Small for Gestational Age / growth & development*
Nitrogen / metabolism*
Proteins / metabolism*
Weight Gain
Reg. No./Substance:
0/Dietary Proteins; 0/Proteins; 7727-37-9/Nitrogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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