Document Detail

Nitro-l-arginine attenuates SKF 38393-induced oral activity in neonatal 6-hydroxydopamine-lesioned rats.
MedLine Citation:
PMID:  9519546     Owner:  NLM     Status:  MEDLINE    
Nitric oxide (NO) in brain has been implicated in neuronal regulatory processes and in neuropathologies. Previously we showed that NO modified quinpirole-induced yawning, a behavioral measure of dopamine (DA) D3 receptor activation in rats. The aim of this study was to characterize the effect of nitro-L-arginine methyl ester HCl (NAME) and L-arginine HCl on reactivity of rats to the DA D1 receptor agonist SKF 38393 and DA D1 antagonist SCH 23390 in intact and neonatal 6-hydroxydopamine (6-OHDA)-lesioned rats (134 micrograms of base ICV at 3rd day after birth). L-arginine HCl (300 mg/kg i.p.) increased the oral activity response in 6-OHDA-lesioned rats, like SKF 38393, and induced catalepsy in intact control rats, like SCH 23390. In contrast, NAME had no effect on oral activity or catalepsy, but fully attenuated SKF 38393-induced oral activity. These findings indicate that L-arginine HCl has no apparent effect at the DA D1 receptor, but that NAME is effective in attenuating a DA D1 agonist-induced effect. Consequently NO may be an intracellular second messenger for supersensitized receptors associated with DA D1 agonist-induced oral activity.
R Brus; R Szkilnik; P Nowak; R M Kostrzewa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neurobiologiae experimentalis     Volume:  57     ISSN:  0065-1400     ISO Abbreviation:  Acta Neurobiol Exp (Wars)     Publication Date:  1997  
Date Detail:
Created Date:  1998-04-13     Completed Date:  1998-04-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1246675     Medline TA:  Acta Neurobiol Exp (Wars)     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  283-7     Citation Subset:  IM    
Department of Pharmacology, Silesian Academy of Medicine, Zabrze, Poland.
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MeSH Terms
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / pharmacology*
Animals, Newborn
Catalepsy / chemically induced,  physiopathology
Dopamine Agonists / pharmacology*
Drug Interactions
Enzyme Inhibitors / pharmacology*
NG-Nitroarginine Methyl Ester / pharmacology
Nitroarginine / pharmacology*
Rats, Wistar
Yawning / drug effects*
Reg. No./Substance:
0/Dopamine Agonists; 0/Enzyme Inhibitors; 0/Sympatholytics; 1199-18-4/Oxidopamine; 2149-70-4/Nitroarginine; 50903-99-6/NG-Nitroarginine Methyl Ester; 67287-49-4/2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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