| Nitro-aspirin is a potential therapy for non alcoholic fatty liver disease. | |
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MedLine Citation:
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PMID: 21453696 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver injury; however its therapeutic strategy has not been established yet. Nitro-aspirin (NO-aspirin) is a new molecule in which aspirin and a NO-donating group are covalently linked. This study investigated the potential protective effect of NO-aspirin on NAFLD. Experimental rats were assigned into 4 groups. Group 1 fed normal diet and served as normal control group. Group 2 fed 2% cholesterol diet and received vehicle as positive control NAFLD group. Group 3 fed 2% cholesterol diet plus NO-aspirin (100mg/kg/day). Group 4 fed 2% cholesterol diet plus aspirin (55mg/kg/day). Rats were treated for eight weeks. The results showed that NO-aspirin (but not aspirin) prevented the development of NAFLD as evidenced by significant reduction in liver weight/body weight ratio (liver index) and histopathologicaly changes. The protective effect of NO-aspirin accompanied with significant decrease of triglycerides, malondialdehyde (MDA), nitric oxide (NO) in hepatic tissue. Semi-quantitative immunohistochemical studies showed significant decrease in expression of inducible nitric oxide synthase (iNOS) and Cyclooxygenase-2 (COX-2) in hepatic tissue. In conclusion, NO-aspirin inhibited multiple pathways involved in the pathogenesis of NAFLD indicating that it might serve as a new therapeutic strategy. |
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Authors:
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Mohamed Ibrahim; Entesar Farghaly; Wafaey Gomaa; Mina Kelleni; Aly Mohamed Abdelrahman |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-28 |
Journal Detail:
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Title: European journal of pharmacology Volume: - ISSN: 1879-0712 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-4-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2010. Published by Elsevier B.V. |
Affiliation:
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Department of Pharmacology, Faculty of Medicine, Minia University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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