| Nitrites in induced sputum as a simple and cheap non-invasive marker of airway inflammation for asthmatic schoolchildren. | |
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MedLine Citation:
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PMID: 18167157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine if there are differences in the nitric oxide metabolites (nitrites) in sputum of patients with persistent asthma and healthy schoolchildren, we performed a case-control study in a tertiary care hospital in Arequipa, Perú. Nitrites in induced sputum samples were measured using the Griess assay in 30 persistent asthmatics (mean age of 10.1 yr) and 30 controls (mean age of 11.9 yr). The mean +/- s.d. of nitrites among asthmatics was significantly higher than the controls (16.30 +/- 8.6 vs. 10.25 +/- 4.68 nmol/ml, respectively, p = 0.001). Moreover, the nitrite level in the sputum in children with severe persistent asthma was higher than in the level found in the moderate and mild asthmatics (32.83 +/- 9.48 vs. 18.10 +/- 1.96 vs. 11.84 +/- 4.73 nmol/ml, respectively, p < 0.01 for linear trend). This study showed for the first time in children that asthmatics have significantly higher levels of nitrites in induced sputum than healthy controls and that the level of nitrite correlates with the severity of the asthma. Nitrite levels in sputum, a simple and cheap, non-invasive method, may be a good alternative to measure the severity of inflammation in asthmatic children. |
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Authors:
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Arturo Recabarren; Carlos Apaza; José A Castro-Rodríguez |
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Publication Detail:
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Type: Journal Article Date: 2007-12-27 |
Journal Detail:
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Title: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology Volume: 19 ISSN: 1399-3038 ISO Abbreviation: Pediatr Allergy Immunol Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-20 Completed Date: 2008-11-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9106718 Medline TA: Pediatr Allergy Immunol Country: England |
Other Details:
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Languages: eng Pagination: 433-7 Citation Subset: IM |
Affiliation:
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Hospital III Yanahuara EsSalud and Universidad Nacional San Agustín, Arequipa, Perú |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Asthma
/
diagnosis,
immunology*,
metabolism,
physiopathology Biological Markers* Bronchial Hyperreactivity / diagnosis, physiopathology Case-Control Studies Child Female Humans Inflammation Male Nitrites / chemistry, metabolism* Respiratory System / immunology, physiopathology Severity of Illness Index Sputum / chemistry*, immunology |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Nitrites |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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