| Nitrite modulates contractility of teleost (Anguilla anguilla and Chionodraco hamatus, i.e. the Antarctic hemoglobinless icefish) and frog (Rana esculenta) hearts. | |
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MedLine Citation:
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PMID: 19298789 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Being the largest form of intravascular and tissue storage of nitric oxide (NO) and a signalling molecule itself, the nitrite anion (NO(2)(-)) has emerged as a key player in many biological processes. Since the heart is under an important NO-mediated autocrine-paracrine control, in mammals the cardiac effects of nitrite are under intensive investigation. In contrast, nothing is known in non-mammalian vertebrates. We evaluated nitrite influence on cardiac performance in the perfused beating heart of three different cold-blooded vertebrates, i.e. two teleost fishes, the temperate red-blooded Anguilla anguilla, the Antarctic stenotherm, hemoglobinless Chionodraco hamatus (icefish), and the frog Rana esculenta. We showed that, under basal conditions, in all animals nitrite influences cardiac mechanical performance, inducing negative inotropism in eel and frog, while being a positive inotrope in C. hamatus. In all species, these responses parallel the inotropic effects of authentic NO. We also demonstrated that the nitrite-dependent inotropic effects are i) dependent from NO synthase (NOS) activity in fish; ii) sensitive to NO scavenging in frog; iii) cGMP/PKG-dependent in both eel and frog. Results suggest that nitrite is an integral physiological source of NO and acts as a signalling molecule in lower vertebrate hearts, exerting relevant inotropic actions through different species-specific mechanisms. |
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Authors:
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M C Cerra; T Angelone; M L Parisella; D Pellegrino; B Tota |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-03-17 |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1787 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-15 Completed Date: 2009-08-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 849-55 Citation Subset: IM |
Affiliation:
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Department of Pharmaco-Biology, University of Calabria, 87030 Arcavacata di Rende, CS, Italy. cerramc@unical.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anguilla
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metabolism* Animals Antarctic Regions Female Male Myocardial Contraction / drug effects* Myocardium / metabolism Nitrites / pharmacology* Oceans and Seas Perciformes / metabolism* Rana esculenta / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Nitrites |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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