Document Detail


Nitrite-induced iron deficiency in the neonatal rat.
MedLine Citation:
PMID:  3188025     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Neonatal rats from dams receiving 2 or 3 g NaNO2/liter in the drinking water through -gestation and lactation suffered severe microcytic anemia as well as growth retardation and high mortality. Lipemia, fatty liver damage, decreased erythropoiesis of spleen and bone marrow, and reduced plasma and tissue iron levels were noted in affected pups. These effects were all consistent with and characteristic of iron deficiency. Experiments presented here were designed to show that the maternally mediated toxicity of nitrite is actually an iron deficiency syndrome in the pups caused by inadequate iron transfer from dam to pup. It was found that administration of exogenous iron supplement to pups of treated mothers reversed the anemia and other effects of nitrite toxicity noted both in previous studies and in unsupplemented littermates. Mothers of affected pups were themselves anemic. Finally, we fully documented severe iron deficiency in pups of nitrite-treated mothers and showed that these mothers produced milk of reduced iron content. It appears then that nitrite-consuming dams have a reduced capacity to transfer iron to their pups. The nitrite-associated toxicities in the pups are actually a result of an iron deficiency.
Authors:
A C Roth; M K Smith
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology and applied pharmacology     Volume:  96     ISSN:  0041-008X     ISO Abbreviation:  Toxicol. Appl. Pharmacol.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1988-12-20     Completed Date:  1988-12-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0416575     Medline TA:  Toxicol Appl Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  43-51     Citation Subset:  IM    
Affiliation:
U.S. Environmental Protection Agency, Toxicology and Microbiology Division, Cincinnati, Ohio 45268.
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MeSH Terms
Descriptor/Qualifier:
Anemia / chemically induced
Animals
Animals, Newborn / metabolism*
Female
Iron / deficiency*
Lactation
Maternal-Fetal Exchange
Nitrites*
Pregnancy
Rats
Weight Gain
Chemical
Reg. No./Substance:
0/Nitrites; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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