Document Detail

Nitric oxide used to test pulmonary gas exchange in rabbits.
MedLine Citation:
PMID:  9817792     Owner:  NLM     Status:  MEDLINE    
To evaluate whether nitric oxide (NO) is an appropriate test gas for assessing pulmonary gas exchange, we determined the rates of disappearance from the alveolar space (lambda) of NO and singly and doubly 18O-labelled carbon dioxide (C16O18O, C18O2) by performing single-breath manoeuvres on seven artificially ventilated rabbits. By exploiting unique features of both isotopic species and by analysing pulmonary gas transport and lambda values with a commonly used model, we found that diffusion forms 98+/-6% (mean +/- SD) of the overall resistance to alveolar-capillary NO transfer. This means that measurements of pulmonary NO uptake reveal the entire diffusive properties of the alveolar-capillary membrane, because the extremely fast binding of NO to haemoglobin negates the "reactive" component within red blood cells of pulmonary capillaries.
H Heller; K Schuster
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  437     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-03-09     Completed Date:  1999-03-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  94-7     Citation Subset:  IM    
Department of Physiology, University of Bonn, Nussallee 11, D-53115 Bonn, Germany.
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MeSH Terms
Breath Tests
Carbon Monoxide
Hemoglobins / metabolism
Nitric Oxide / diagnostic use*,  metabolism,  pharmacokinetics
Oxygen Isotopes
Pulmonary Alveoli / metabolism
Pulmonary Gas Exchange*
Reg. No./Substance:
0/Hemoglobins; 0/Oxygen Isotopes; 10102-43-9/Nitric Oxide; 630-08-0/Carbon Monoxide

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