| Nitric oxide and thermoregulation during exercise in the horse. | |
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MedLine Citation:
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PMID: 9104835 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of inhibition of nitric oxide production on sweating rate (SR) and on core, rectal, and tail skin temperatures was measured in five Thoroughbred horses during exercise of variable intensity on a high-speed treadmill. A standard exercise test consisting of three canters [approximately 55% maximum O2 uptake (VO2max)], with walking (approximately 9% VO2max) and trotting (approximately 22% VO2max) between each canter, was performed twice (control or test), in random order, by each horse. N(G)-nitro-L-arginine methyl ester (L-NAME; 20 mg/kg), a competitive inhibitor of nitric oxide synthase, was infused into the central circulation and induced a significant reduction in the SR measured on the neck (31.6 +/- 6.4 vs. 9.7 +/- 4.2 g x min(1) x m(-2); 69%) and rump (14.7 +/- 5.2 vs. 4.8 +/- 1.6 g x min(-1) x m(-2); 67%) of the horses during canter (P < 0.05). Significant increases in core, rectal, and tail skin temperatures were also measured (P < 0.05). L-Arginine (200 mg/kg iv) partially reversed the inhibitory effects of L-NAME on SR, but core, rectal, and tail skin temperatures continued to increase (P < 0.05), suggesting a cumulation of body heat. The results support the contention that nitric oxide synthase inhibition diminishes SR, resulting in elevated core and peripheral temperatures leading to deranged thermoregulation during exercise. The inhibition of sweating by L-NAME may be related to peripheral vasoconstriction but may also involve the neurogenic control of sweating. |
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Authors:
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P C Mills; D J Marlin; C M Scott; N C Smith |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 82 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1997 Apr |
Date Detail:
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Created Date: 1997-06-26 Completed Date: 1997-06-26 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1035-9 Citation Subset: IM |
Affiliation:
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Equine Centre, The Animal Health Trust, Newmarket, Suffolk, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arginine / pharmacology Body Temperature Regulation / physiology* Enzyme Inhibitors / pharmacology Exercise Test Female Horses / physiology* Male NG-Nitroarginine Methyl Ester / pharmacology Nitric Oxide / physiology* Nitric Oxide Synthase / antagonists & inhibitors Oxygen Consumption / drug effects, physiology Physical Exertion / physiology* Skin Physiological Phenomena Sweating / physiology |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; 74-79-3/Arginine; EC 1.14.13.39/Nitric Oxide Synthase |
| Comments/Corrections | |
Comment In:
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J Appl Physiol. 1997 Apr;82(4):1033-4
[PMID:
9104834
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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