Document Detail


Nitric oxide synthases and tubal ectopic pregnancies induced by Chlamydia infection: basic and clinical insights.
MedLine Citation:
PMID:  20647263     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human ectopic pregnancy (EP) remains a common cause of pregnancy-related first trimester death. Nitric oxide (NO) is synthesized from L-arginine by three NO synthases (NOS) in different tissues, including the Fallopian tube. Studies of knockout mouse models have improved our understanding of the function of NOS isoforms in reproduction, but their roles and specific mechanisms in infection-induced tubal dysfunction have not been fully elucidated. Here, we provide an overview of the expression, regulation and possible function of NOS isoforms in the Fallopian tube, highlighting the effects of infection-induced changes in the tubal cellular microenvironment (imbalance of NO production) on tubal dysfunction and the potential involvement of NOS isoforms in tubal EP after Chlamydia trachomatis genital infection. The non-equivalent regulation of tubal NOS isoforms during the menstrual cycle suggests that endogenous ovarian steroid hormones regulate NOS in an isoform-specific manner. The current literature suggests that infection with C. trachomatis induces an inflammatory response that eventually leads to tubal epithelial destruction and functional impairment, caused by a high NO output mediated by inducible NOS (iNOS). Therefore, tissue-specific therapeutic approaches to suppress iNOS expression may help to prevent ectopic implantation in patients with prior C. trachomatis infection of the Fallopian tube.
Authors:
Ruijin Shao; Sean X Zhang; Birgitta Weijdegård; Shien Zou; Emil Egecioglu; Anders Norström; Mats Brännström; Håkan Billig
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-07-20
Journal Detail:
Title:  Molecular human reproduction     Volume:  16     ISSN:  1460-2407     ISO Abbreviation:  Mol. Hum. Reprod.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-03-16     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  9513710     Medline TA:  Mol Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  907-15     Citation Subset:  IM    
Affiliation:
Department of Physiology/Endocrinology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. ruijin.shao@fysiologi.gu.se
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle
Chlamydia Infections / complications*,  enzymology
Chlamydia trachomatis*
Fallopian Tube Diseases / enzymology,  microbiology,  pathology
Fallopian Tubes / enzymology*,  microbiology,  pathology
Female
Gene Expression Regulation
Humans
Isoenzymes / genetics,  metabolism,  physiology
Mice
Nitric Oxide Synthase / genetics,  metabolism,  physiology*
Pregnancy
Pregnancy Complications, Infectious / enzymology*,  epidemiology,  microbiology
Pregnancy, Ectopic / enzymology,  epidemiology,  microbiology*
Rats
Chemical
Reg. No./Substance:
0/Isoenzymes; EC 1.14.13.39/Nitric Oxide Synthase
Comments/Corrections

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