| Nitric oxide synthases II and III and vascular endothelial growth factor are up-regulated in sciatic nerve after spiral cuff electrode implantation. | |
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MedLine Citation:
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PMID: 16038988 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nerve cuff electrodes, commonly used in functional electrical stimulation systems, induce local morphological changes that can affect nerve functionality. Nitric oxide (NO) and vascular endothelial growth factor (VEGF) have both neural and vascular effects. We investigated the time-dependent regulation of nitric oxide synthases (NOS) and of VEGF after implantation of spiral cuff electrode around rat sciatic nerve. NOSIII as well as VEGF were up-regulated in both epineurial and endoneurial compartments in cuff-implanted animals along with microvascular changes. Our results suggest that VEGF and NO are implied in morphological and functional alterations occurring in the early time after cuff implantation. |
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Authors:
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Marie-Anne Thil; Valérie Vince; Claude Veraart; Jean Delbeke; Ides M Colin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 166 ISSN: 0165-5728 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-08-02 Completed Date: 2005-09-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 158-66 Citation Subset: IM |
Affiliation:
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Laboratoire de Génie de la Réabilitation Neurale, Medical School, Brussels, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Vessels / metabolism, pathology Blotting, Western Electrodes, Implanted* Immunohistochemistry Microcirculation Neuritis / etiology, pathology Nitric Oxide Synthase / metabolism* Nitric Oxide Synthase Type II Nitric Oxide Synthase Type III Rats Sciatic Nerve / blood supply, metabolism*, pathology Up-Regulation Vascular Endothelial Growth Factor A / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Vascular Endothelial Growth Factor A; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.14.13.39/Nitric Oxide Synthase Type II; EC 1.14.13.39/Nitric Oxide Synthase Type III; EC 1.14.13.39/Nos2 protein, rat; EC 1.14.13.39/Nos3 protein, rat |
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