| Nitric oxide synthase inhibition increases vascular resistance in sodium and water loaded rats. | |
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MedLine Citation:
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PMID: 9820901 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to investigate whether nitric oxide might be involved in the adaptation of the cardiovascular system in sodium and water loaded organisms. The effects of a semi-chronic (4 day) inhibition of nitric oxide production were studied in normovolemic and per os sodium and water loaded rats. Nitric oxide synthase was inhibited by L-NAME (10 mg/kg in normovolemic and 14 mg/kg in sodium loaded rats) dissolved in the drinking solution. Blood pressure, cardiac output (Stewart-Hamilton's principle) and its regional fractions (Sapirstein's technique using 86Rb isotope as indicator), total peripheral resistance and regional vascular resistances were determined on the 5th day in sodium pentobarbital anaesthesia. The increase in blood pressure following L-NAME pretreatment in both groups was similar, but the elevation of total peripheral resistance was 106% in normovolemic and only 30% in sodium loaded animals. The cardiac output decreased by 44% in normovolemic and 14% in sodium loaded groups after nitric oxide synthase inhibition. The organ vascular resistances increased and organ blood flows decreased after L-NAME administration. These changes were less pronounced in sodium and water load, especially those in the skeletal muscle and intestine. Nitric oxide-induced changes in vascular resistance are more pronounced in normovolemia than in sodium load; sodium load might influence the nitric oxide production. The share of nitric oxide in the setting of vascular tone is different in the various organs. |
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Authors:
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C Hably; J Vág; J Bartha |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie Volume: 198 ISSN: 0300-9130 ISO Abbreviation: Res Exp Med (Berl) Publication Date: 1998 Oct |
Date Detail:
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Created Date: 1999-03-01 Completed Date: 1999-03-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0324736 Medline TA: Res Exp Med (Berl) Country: GERMANY |
Other Details:
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Languages: eng Pagination: 145-56 Citation Subset: IM |
Affiliation:
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Department of Physiology, Semmelweis University of Medicine, Budapest, Hungary. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Blood Pressure / drug effects* Enzyme Inhibitors / pharmacology* Female Hemodynamics / drug effects NG-Nitroarginine Methyl Ester / pharmacology* Nitric Oxide Synthase / antagonists & inhibitors*, physiology Rats Rats, Wistar Sodium Chloride / administration & dosage, pharmacology Vascular Resistance / drug effects* Water / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 50903-99-6/NG-Nitroarginine Methyl Ester; 7647-14-5/Sodium Chloride; 7732-18-5/Water; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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