Document Detail

Nitric oxide synthase inhibition and food intake: effects on motivation to eat and in female mice.
MedLine Citation:
PMID:  7542389     Owner:  NLM     Status:  MEDLINE    
Recent studies have demonstrated that nitric oxide may play an important role in the regulation of food intake. The studies reported here extend these findings by demonstrating that NG-nitro-arginine-methylester, N-Arg(ME), a nitric oxide synthase inhibitor, decreased intake of a highly palatable substance (i.e., milk), though at a higher dose than necessary for decreasing consumption of food pellets. N-Arg(ME) failed to inhibit lever press for milk reward in nonprefed mice, but decreased lever pressing in prefed mice. N-Arg(ME) decreased food intake in female mice, being most potent in proestrus. These studies suggest that nitric oxide synthase inhibition decreases food intake without inducing aversion or illness.
J E Morley; S A Farr; M D Suarez; J F Flood
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  50     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-08-22     Completed Date:  1995-08-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  369-73     Citation Subset:  IM    
Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, St. Louis, MO 63106, USA.
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MeSH Terms
Amino Acid Oxidoreductases / antagonists & inhibitors*
Arginine / analogs & derivatives,  pharmacology
Conditioning, Operant / drug effects*
Drinking Behavior / drug effects
Feeding Behavior / drug effects*
NG-Nitroarginine Methyl Ester
Nitric Oxide / antagonists & inhibitors
Nitric Oxide Synthase
Reg. No./Substance:
10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; 74-79-3/Arginine; EC Oxide Synthase; EC 1.4.-/Amino Acid Oxidoreductases

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