| Nitric oxide supports atrial function in sepsis: relevance to side effects of inhibitors in shock. | |
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MedLine Citation:
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PMID: 12167470 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mechanisms underlying myocardial dysfunction in sepsis remain poorly understood. The theoretical benefits of nitric oxide synthase (NOS) inhibition in reversing the haemodynamic changes that characterise septic shock have not been supported by clinical trials, some of which have demonstrated detrimental myocardial effects. We have therefore assessed the effects of endotoxaemia on NOS enzyme expression as well as a number of functional responses of myocardial tissue from rats. Atrial tissue expressed high levels of mRNA for inducible (i) NOS and released increased levels of nitrite after animals were treated with endotoxin. In parallel, the inotropic response stimulated by isoprenaline was reduced in atria from endotoxin-treated animals, an effect that was reversed when endogenous release of NO was maximised. Our results suggest that myocardial contractility is maintained by NO production and that inhibitors may compromise cardiac output; this may explain the deleterious effects of NOS inhibition on cardiac function in clinical trials. |
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Authors:
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Susanna Price; Timothy W Evans; Jane A Mitchell |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of pharmacology Volume: 449 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-08-08 Completed Date: 2003-02-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 279-85 Citation Subset: IM |
Affiliation:
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Unit of Critical Care Medicine, Imperial College School of Medicine, National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atrial Natriuretic Factor / metabolism Cell Death / drug effects Electric Stimulation Enzyme Inhibitors / pharmacology Heart / drug effects*, physiopathology* Heart Atria / drug effects L-Lactate Dehydrogenase / metabolism Lipopolysaccharides / toxicity Male Myocardial Contraction / drug effects Myocardium / pathology Nitric Oxide / metabolism, physiology* Nitric Oxide Synthase / antagonists & inhibitors*, metabolism Nitric Oxide Synthase Type I Nitric Oxide Synthase Type II Nitric Oxide Synthase Type III Organ Culture Techniques Rats Salmonella enteritidis / chemistry Sepsis / pathology, physiopathology* Shock, Septic / pathology, physiopathology* omega-N-Methylarginine / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Lipopolysaccharides; 10102-43-9/Nitric Oxide; 17035-90-4/omega-N-Methylarginine; 85637-73-6/Atrial Natriuretic Factor; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 1.14.13.39/Nitric Oxide Synthase; EC 1.14.13.39/Nitric Oxide Synthase Type I; EC 1.14.13.39/Nitric Oxide Synthase Type II; EC 1.14.13.39/Nitric Oxide Synthase Type III; EC 1.14.13.39/Nos1 protein, rat; EC 1.14.13.39/Nos2 protein, rat; EC 1.14.13.39/Nos3 protein, rat |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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