| Nitric oxide-supplemented resuscitation improves early gastrointestinal blood flow in rats subjected to hemorrhagic shock without late consequences. | |
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MedLine Citation:
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PMID: 20883974 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: we have shown that hemorrhage/resuscitation altered gastrointestinal blood flow (GI-BF) and that gastric perfusion did not recover after resuscitation. This study aimed to determine the effect of nitric oxide (NO) supplemented resuscitation on the mean arterial blood pressure (MAP), GI-BF, and outcome after hemorrhagic shock. METHODS: rats were subjected to hemorrhage and resuscitation with/without the NO-donor S-nitroso human serum albumin (S-NO-HSA). GI-BF was determined using colored microspheres. RESULTS: NO supplementation significantly decreased MAP at the end of resuscitation. At the same time point, the GI-BF has significantly increased in the stomach, duodenum, and colon. Two hours after treatment discontinuation, there was no difference in either MAP or GI-BF between NO-supplemented and control groups. The survival times indicated that S-NO-HSA treatment was noninferior compared with control. CONCLUSIONS: NO-supplemented resuscitation improves the GI-BF during the early stage of resuscitation without a negative impact on short-/long-term survival despite a transient MAP decrease. |
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Authors:
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Babak Sobhian; Mohammad Jafarmadar; Heinz Redl; Soheyl Bahrami |
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Publication Detail:
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Type: Journal Article Date: 2010-09-29 |
Journal Detail:
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Title: American journal of surgery Volume: 201 ISSN: 1879-1883 ISO Abbreviation: Am. J. Surg. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-20 Completed Date: 2011-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370473 Medline TA: Am J Surg Country: United States |
Other Details:
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Languages: eng Pagination: 100-10 Citation Subset: AIM; IM |
Copyright Information:
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2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Ludwig Boltzmann Institute of Experimental and Clinical Traumatology and Research Center of the Allgemeine Unfallversicherungsanstalt, Donaueschingenstr 13, A-1200, Vienna, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects* Fluid Therapy Gastrointestinal Tract / blood supply*, drug effects Male Nitroso Compounds / administration & dosage* Rats Rats, Sprague-Dawley Serum Albumin, Bovine / administration & dosage* Shock, Hemorrhagic / complications, mortality, therapy* Vasodilator Agents / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Nitroso Compounds; 0/S-nitrosoalbumin; 0/Serum Albumin, Bovine; 0/Vasodilator Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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