| Nitric oxide release from coronary vasculature before, during, and following cardioplegic arrest. | |
| | |
MedLine Citation:
|
PMID: 10552116 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Nitric oxide (NO) is known as a vasodilatory molecule synthesized by vascular endothelium. The NO-dependent vasodilatory response of coronary artery is impaired after ischemia and reperfusion. In the present study, the release of NO from coronary vasculature was evaluated before and during cardioplegic arrest and after reperfusion. Nine patients undergoing heart surgery were studied. Multidose crystalloid cardioplegics were used for myocardial protection. The coronary affluent and effluent were obtained simultaneously before cardioplegic arrest, at each cardioplegic administration, and after reperfusion; and the levels of nitrite and nitrate, the stable end-products of NO, were measured. The NO release from the coronary vasculature was determined as the difference in the levels of nitrite and nitrate between the coronary effluent and affluent. The level of nitrite/nitrate release from coronary vasculature was 6.8 +/- 3.7 microM before cardioplegic arrest. During cardioplegic arrest the nitrite/nitrate release decreased, reaching 1.3 +/- 1.3 microM (p < 0.05, vs. before cardioplegic arrest) at the fourth administration of the cardioplegic. At 3 to 5 minutes after reperfusion, nitrite/nitrate release further decreased to 0.36 +/- 0.34 microM (p < 0.05, vs. before cardioplegic arrest). During cardioplegic arrest the NO release decreased and reached significance at approximately 70 minutes of cardioplegic arrest compared to that before cardioplegic arrest. After reperfusion, NO release was further reduced, with statistical significance compared to that before cardioplegic arrest. Our data may indicate that cardioplegic arrest and reperfusion cause endothelial dysfunction. |
| | |
Authors:
|
H Gohra; Y Fujimura; K Hamano; H Noda; T Katoh; N Zempo; K Esato; T Ueda; D Sadamitsu; T Maekawa |
Related Documents
:
|
2133846 - Another look at cardiac xenotransplantation. 21723516 - Detection of myocardial perfusion abnormalities using ultra-low radiation dose regadeno... 2064096 - Comparison of standard external cpr, open-chest cpr, and cardiopulmonary bypass in a ca... 14768926 - Resuscitation after cardiac surgery: are we ageist? 20365016 - Phase statistics approach to human ventricular fibrillation. 2359076 - A controlled clinicopathologic study of myocardial fibrosis in systemic sclerosis (scle... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: World journal of surgery Volume: 23 ISSN: 0364-2313 ISO Abbreviation: World J Surg Publication Date: 1999 Dec |
Date Detail:
|
Created Date: 1999-12-10 Completed Date: 1999-12-10 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7704052 Medline TA: World J Surg Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1249-53 Citation Subset: IM |
Affiliation:
|
First Department of Surgery, Yamaguchi University School of Medicine, 1144 Kogushi, Ube, Yamaguchi 755, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Analysis of Variance Blood Vessel Prosthesis Implantation Cardiopulmonary Bypass Coronary Vessels / metabolism* Female Heart Arrest, Induced* Heart Valve Prosthesis Implantation Humans Male Middle Aged Nitric Oxide / metabolism* |
| Chemical | |
Reg. No./Substance:
|
10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Principles of economic evaluation in surgery.
Next Document: Penetrating cardiac trauma: follow-up study including electrocardiography, echocardiography, and fun...