Document Detail

Nitric oxide regulation of microvascular oxygen.
MedLine Citation:
PMID:  17508909     Owner:  NLM     Status:  MEDLINE    
The role of nitric oxide (NO) as a highly diffusible free radical gaseous vasodilator is intrinsically linked to the control of blood flow and oxygen (O(2)) delivery to tissue. NO also is involved in regulating mitochondrial O(2) metabolism, growth of new blood vessels, and blood oxygenation through control of respiratory ventilation. Hemoglobin and myoglobin may help to conserve NO for subsequent release of a NO-related vasoactive species under hypoxic conditions. NO has a major role in regulating microvascular O(2), and dysfunctional NO signaling is associated with the pathogenesis of metabolic and cardiovascular diseases.
Donald G Buerk
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  9     ISSN:  1523-0864     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-05-18     Completed Date:  2007-09-11     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  829-43     Citation Subset:  IM    
Departments of Physiology and Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
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MeSH Terms
Cardiovascular Diseases / blood,  metabolism,  physiopathology
Models, Biological
Nitric Oxide / metabolism,  physiology*
Nitric Oxide Synthase / metabolism
Oxygen / blood,  metabolism*
Signal Transduction / physiology*
Vasodilation / physiology*
Grant Support
Reg. No./Substance:
10102-43-9/Nitric Oxide; 7782-44-7/Oxygen; EC Oxide Synthase

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